RNA splicing is a primary link between genetic variation and disease

Yang Li, Bryce van de Geijn, Anil Raj, +5

Science

WASP: allele-specific software for robust molecular quantitative trait locus discovery

Bryce van de Geijn, Graham McVicker, Yoav Gilad, +1

Nature Methods

Genome-wide Association StudyGenetic AnalysisAllelic VariantFunctional GenomicsQuantitative Genetics +12

Identification of Genetic Variants That Affect Histone Modifications in Human Cells

Graham McVicker, Bryce van de Geijn, Jacob F. Degner, +7

Science

Functionally informed fine-mapping and polygenic localization of complex trait heritability

Omer Weissbrod, Farhad Hormozdiari, Christian Benner, +11

Nature Genetics

Genetic AnalysisDevelopmental BiologyQuantitative GeneticsGenotype-phenotype AssociationGenetics +8

Methylation QTLs Are Associated with Coordinated Changes in Transcription Factor Binding, Histone Modifications, and Gene Expression Levels

Nicholas E. Banovich, Xun Lan, Graham McVicker, +6

PLoS Genetics

Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits

Farhad Hormozdiari, Steven Gazal, Bryce van de Geijn, +10

Nature Genetics

Genome-wide Association StudyGenetic AnalysisGenetic DiseasesComplex Trait GeneticsQuantitative Genetics +12

Disease Heritability Enrichment of Regulatory Elements Is Concentrated in Elements with Ancient Sequence Age and Conserved Function across Species

Margaux L.A. Hujoel, Steven Gazal, Farhad Hormozdiari, +2

The American Journal of Human Genetics

Disease Heritability EnrichmentGeneticsGenetic EpidemiologyGene CharacterizationMolecular Genetics +15

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

Yakir Reshef, Hilary K. Finucane, David R. Kelley, +16

Nature Genetics

Genome-wide Association StudyGenome-wide Directional EffectsGeneticsPolygenic RiskGenetic Epidemiology +11

Genes with High Network Connectivity Are Enriched for Disease Heritability

Samuel S. Kim, Chengzhen L. Dai, Farhad Hormozdiari, +9

The American Journal of Human Genetics

IMPACT: Genomic Annotation of Cell-State-Specific Regulatory Elements Inferred from the Epigenome of Bound Transcription Factors

Tiffany Amariuta, Yang Luo, Steven Gazal, +9

The American Journal of Human Genetics