Concepedia

Complement-mediated Recognition

Complement-Mediated Recognition is a host-pathogen recognition mechanism in which the complement system, a component of the innate immune system, directly identifies and binds to pathogen-associated molecular patterns or opsonizes pathogens through cascade activation, thereby distinguishing microbial surfaces from host cells via differential recognition of surface chemistry and regulation by host complement inhibitors.

149

Publications

8.7K

Citations

752

Authors

276

Institutions

Publications per year

2017–2026

20

Parents

Publications

149

The classical pathway is the dominant complement pathway required for innate immunity to <i>Streptococcus pneumoniae</i> infection in mice

Jeremy Brown, Tracy Hussell, Sarah M. Gilliland et al. · Proceedings of the National Academy of Sciences · 2002 · 366 citations · Full text

, , +17

The Crystal Structure of the Globular Head of Complement Protein C1q Provides a Basis for Its Versatile Recognition Properties

Christine Gaboriaud, Arnaud Gruez, Monique Lacroix et al. · Journal of Biological Chemistry · 2003 · 360 citations · Full text

, , +17

Properdin Can Initiate Complement Activation by Binding Specific Target Surfaces and Providing a Platform for De Novo Convertase Assembly

Dirk Spitzer, Lynne M. Mitchell, John P. Atkinson et al. · The Journal of Immunology · 2007 · 280 citations · Full text

, , +15

Structural basis for sialic acid–mediated self-recognition by complement factor H

Bärbel S. Blaum, Jonathan P. Hannan, Andrew P. Herbert et al. · Nature Chemical Biology · 2014 · 280 citations

, , +16

Sensitization of Gram-negative bacteria to antibiotics and complement by a nontoxic oligopeptide

Martti Vaara, Timo Vaara · Nature · 1983 · 234 citations

, , +14

1–5 of 149

Authors

752

  1. NM
    Nicole M. Thielens

    Institut de Biologie Structurale, France

    5 publications · 205 citations

    5

    h-index

  2. RP
    Ronald P. Taylor

    University of Virginia, United States

    5 publications · 159 citations

    5

    h-index

  3. ML
    Michael Loos

    Johannes Gutenberg University Mainz, Germany

    5 publications · 217 citations

    5

    h-index

  4. GJ
    Gérard J. Arlaud

    Institut de Biologie Structurale, France

    4 publications · 528 citations

    4

    h-index

  5. CG
    Christine Gaboriaud

    Institut de Biologie Structurale, France

    4 publications · 453 citations

    4

    h-index

1–5 of 752

Institutions

276

  1. Institut de Biologie Structurale

    Grenoble, France

    7 h-index

    38 publications

    2.3K citations

  2. Université Grenoble Alpes

    Saint-Martin-d'Hères, France

    7 h-index

    38 publications

    2.3K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    6 h-index

    29 publications

    2.1K citations

  4. Commissariat à l'Énergie Atomique et aux Énergies Alternatives

    Paris, France

    6 h-index

    35 publications

    2.5K citations

  5. Utrecht University

    Utrecht, The Netherlands

    5 h-index

    15 publications

    1.3K citations

  6. University of Virginia

    Charlottesville, United States

    5 h-index

    29 publications

    946 citations

  7. University of Helsinki

    Helsinki, Finland

    4 h-index

    10 publications

    729 citations

  8. CEA Grenoble

    Grenoble, France

    4 h-index

    19 publications

    1.5K citations

1–8 of 276

Venues

  1. The Journal of Immunology

    JI · 26 publications · 1.7K citations

    23

    h-index

  2. Infection and Immunity

    IAI · 18 publications · 1.1K citations

    15

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 8 publications · 958 citations

    8

    h-index

  4. PLoS ONE

    7 publications · 258 citations

    7

    h-index

  5. Molecular Immunology

    6 publications · 201 citations

    6

    h-index

1–5