Chromatin Damage is a type of structural and functional alteration in chromatin organization that disrupts genomic integrity and gene expression patterns, primarily resulting from endogenous or exogenous genotoxic stressors.
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ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks
Sandeep Burma, Benjamin P. Chen, Michael Murphy et al. · Journal of Biological Chemistry · 2001 · 1.9K citations · Full text
Calcium‐activated DNA fragmentation kills immature thymocytes
David J. McConkey, Pia Hartzell, Pierluigi Nicotera et al. · The FASEB Journal · 1989 · 529 citations
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