Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

Jiang-bo Tang, Nam Woo Cho, Gaofeng Cui, +5

Nature Structural & Molecular Biology

Histone ModificationsChromatinGenome InstabilityTranscriptional RegulationChromatin Structure +13

T Cell Factor 1 Is Required for Group 2 Innate Lymphoid Cell Generation

Qi Yang, Laurel A. Monticelli, Steven A. Saenz, +12

Immunity

Group 2Autoimmune DiseaseAdaptive Immune SystemT-regulatory CellImmunology +9

Overcoming Temozolomide Resistance in Glioblastoma via Dual Inhibition of NAD+ Biosynthesis and Base Excision Repair

Eva M. Goellner, Bradford Grimme, Ashley R. Brown, +7

Cancer Research

Biallelic Deleterious <i>BRCA1</i> Mutations in a Woman with Early-Onset Ovarian Cancer

Susan M. Domchek, Jiang-bo Tang, Jill E. Stopfer, +13

Cancer Discovery

N-methylpurine DNA glycosylase and DNA polymerase β modulate BER inhibitor potentiation of glioma cells to temozolomide

Jiang-bo Tang, David Svilar, Ram N. Trivedi, +7

Neuro-Oncology

N-methylpurine Dna GlycosylaseHigh-grade GliomasCancer BiologyGliomaParp-mediated Potentiation +14

Human Methyl Purine DNA Glycosylase and DNA Polymerase β Expression Collectively Predict Sensitivity to Temozolomide

Ram N. Trivedi, Xiaohong Wang, Elena Jelezcova, +3

Molecular Pharmacology

Bioenergetic Metabolites Regulate Base Excision Repair–Dependent Cell Death in Response to DNA Damage

Jiang-bo Tang, Eva M. Goellner, Xiaohong Wang, +6

Molecular Cancer Research

Alkylation Sensitivity Screens Reveal a Conserved Cross-species Functionome

David Svilar, Madhu Dyavaiah, Ashley R. Brown, +12

Molecular Cancer Research

EngineeringMolecular BiologyMolecular GeneticsHigh-grade GliomasGlioma +19

Investigation of the mechanical properties of different amorphous composites using the molecular dynamics simulation

Jiang-bo Tang, Aydin Ahmadi, Asˈad Alizadeh, +6

Journal of Materials Research and Technology

EngineeringMechanical EngineeringMaterial SimulationMolecular Dynamics SimulationChemistry +17

Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility

Tuomo Mantere, Anna Tervasmäki, Anna Nurmi, +22

Scientific Reports