Concepedia

Checkpoint Control Of Replication Initiation

Checkpoint Control of Replication Initiation is a regulatory mechanism in cell cycle biology that ensures DNA replication begins only when favorable conditions and genomic integrity are verified, by inhibiting the activation of replication origins in response to DNA damage or unreplicated DNA through signaling pathways mediated by checkpoint kinases.

101

Publications

8.9K

Citations

407

Authors

165

Institutions

Publications per year

2017–2026

12

Parents

Publications

101

A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication

Corrado Santocanale, John F.X. Diffley · Nature · 1998 · 646 citations

, , +14

Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates

Gregor Witte, Sophia Hartung, Katharina Büttner et al. · Molecular Cell · 2008 · 436 citations · Full text

, , +14

An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication

Vincenzo Costanzo, David Shechter, Patrick J. Lupardus et al. · Molecular Cell · 2003 · 344 citations · Full text

, , +16

Chk1 promotes replication fork progression by controlling replication initiation

Eva Petermann, Mick Woodcock, Thomas Helleday · Proceedings of the National Academy of Sciences · 2010 · 304 citations · Full text

, , +17

Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption

Halfdan Beck, Viola Nähse, Marie Sofie Yoo Larsen et al. · Molecular and Cellular Biology · 2012 · 300 citations

, , +17

1–5 of 101

Authors

407

  1. HM
    Hisao Masai

    Tokyo Metropolitan Institute of Medical Science, Japan

    6 publications · 245 citations

    6

    h-index

  2. JF
    John F.X. Diffley

    The Francis Crick Institute, United Kingdom

    5 publications · 1.2K citations

    5

    h-index

  3. PR
    Paul Russell

    Scripps Research Institute, United States

    4 publications · 140 citations

    4

    h-index

  4. BS
    Bruce Stillman

    Cold Spring Harbor Laboratory, United States

    4 publications · 384 citations

    4

    h-index

  5. SM
    Seiji Matsumoto

    Hyogo Medical University, Japan

    4 publications · 122 citations

    4

    h-index

1–5 of 407

Institutions

165

  1. Stanford University

    Stanford, United States

    7 h-index

    17 publications

    1.7K citations

  2. Cancer Research UK

    London, United Kingdom

    6 h-index

    12 publications

    1.2K citations

  3. Cold Spring Harbor Laboratory

    Cold Spring Harbor, United States

    5 h-index

    17 publications

    2.5K citations

  4. Scripps Research Institute

    San Diego, United States

    5 h-index

    14 publications

    1K citations

  5. Wellcome Trust

    London, United Kingdom

    5 h-index

    20 publications

    1.3K citations

  6. The Honourable Society of Lincoln's Inn

    London, United Kingdom

    4 h-index

    6 publications

    988 citations

  7. Cancer Genetics (United States)

    Rutherford, United States

    4 h-index

    16 publications

    770 citations

  8. Massachusetts Institute of Technology

    Cambridge, United States

    4 h-index

    6 publications

    753 citations

1–8 of 165

Venues

  1. Molecular and Cellular Biology

    MCB · 11 publications · 1.1K citations

    11

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 9 publications · 1.1K citations

    9

    h-index

  3. Genes & Development

    6 publications · 534 citations

    6

    h-index

  4. Cell Cycle

    6 publications · 439 citations

    6

    h-index

  5. Molecular Cell

    5 publications · 984 citations

    5

    h-index

1–5