Concepedia

Cell Cycle Checkpoint Dysfunction

Cell Cycle Checkpoint Dysfunction is a biological phenomenon characterized by the failure of regulatory mechanisms that normally pause the cell cycle in response to genomic damage or replication stress, thereby permitting the propagation of cells with unrepaired DNA lesions or incomplete DNA synthesis.

86

Publications

8K

Citations

525

Authors

205

Institutions

Publications per year

2017–2026

10

Parents

Publications

86

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

Michael B. Kastan, Qimin Zhan, Wafik S. El‐Deiry et al. · Cell · 1992 · 3.1K citations

, , +12

Ionizing radiation induces mitochondrial reactive oxygen species production accompanied by upregulation of mitochondrial electron transport chain function and mitochondrial content under control of the cell cycle checkpoint

Tohru Yamamori, Hironobu Yasui, Masayuki Yamazumi et al. · Free Radical Biology and Medicine · 2012 · 392 citations · Full text

, , +16

Exo1 Processes Stalled Replication Forks and Counteracts Fork Reversal in Checkpoint-Defective Cells

Cecilia Cotta‐Ramusino, Daniele Fachinetti, Chiara Lucca et al. · Molecular Cell · 2005 · 267 citations · Full text

, , +15

Histone Deacetylase Inhibitors Trigger a G2 Checkpoint in Normal Cells That Is Defective in Tumor Cells

Ling Qiu, Andrew Burgess, David P. Fairlie et al. · Molecular Biology of the Cell · 2000 · 250 citations · Full text

, , +17

Chk1‐deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

George Zachos, Michael D. Rainey, David A. Gillespie · The EMBO Journal · 2003 · 240 citations · Full text

, , +16

1–5 of 86

Authors

525

  1. BG
    Brian Gabrielli

    The University of Queensland, Australia

    5 publications · 518 citations

    5

    h-index

  2. KK
    Kum Kum Khanna

    QIMR Berghofer Medical Research Institute, Australia

    3 publications · 251 citations

    3

    h-index

  3. SP
    Sandra Pavey

    QIMR Berghofer Medical Research Institute, Australia

    3 publications · 121 citations

    3

    h-index

  4. KB
    Kelly Brooks

    The University of Queensland, Australia

    3 publications · 121 citations

    3

    h-index

  5. HY
    Hushan Yang

    Thomas Jefferson University, United States

    2 publications · 34 citations

    2

    h-index

1–5 of 525

Institutions

205

  1. The University of Texas MD Anderson Cancer Center

    Houston, United States

    6 h-index

    27 publications

    761 citations

  2. The University of Queensland

    Brisbane, Australia

    6 h-index

    32 publications

    2.9K citations

  3. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    6 h-index

    18 publications

    871 citations

  4. QIMR Berghofer Medical Research Institute

    Brisbane, Australia

    5 h-index

    16 publications

    2K citations

  5. National Cancer Institute

    Bethesda, United States

    3 h-index

    17 publications

    9.5K citations

  6. Vanderbilt University

    Nashville, United States

    2 h-index

    2 publications

    48 citations

  7. Columbia University

    New York, United States

    2 h-index

    5 publications

    448 citations

  8. Harold C. Simmons Comprehensive Cancer Center

    Dallas, United States

    2 h-index

    10 publications

    790 citations

1–8 of 205

Venues

  1. PubMed

    Repository · 10 publications · 640 citations

    10

    h-index

  2. Oncogene

    7 publications · 355 citations

    7

    h-index

  3. PLoS ONE

    6 publications · 172 citations

    6

    h-index

  4. Cancer Research

    4 publications · 215 citations

    4

    h-index

  5. Cell Cycle

    3 publications · 168 citations

    3

    h-index

1–5