Concepedia

Caspase Substrate Specificity

Caspase Substrate Specificity is the biochemical determinant that governs the selective recognition and cleavage of peptide sequences by caspases, distinguished by the enzyme's preferential binding to specific amino acid motifs adjacent to the scissile bond.

225

Publications

18.9K

Citations

1K

Authors

312

Institutions

Publications per year

2017–2026

17

Parents

Publications

225

The c‐IAP‐1 and c‐IAP‐2 proteins are direct inhibitors of specific caspases

Natalie Roy · The EMBO Journal · 1997 · 1.3K citations · Full text

, , +14

Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors

Margarita García‐Calvo, Erin P. Peterson, Barbara Leiting et al. · Journal of Biological Chemistry · 1998 · 987 citations · Full text

, , +17

Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma

Uren · Molecular Cell · 2000 · 973 citations

, , +15

Caspase-3 Is Required for α-Fodrin Cleavage but Dispensable for Cleavage of Other Death Substrates in Apoptosis

Reiner U. Jänicke, Patrick Ng, Michael L. Sprengart et al. · Journal of Biological Chemistry · 1998 · 487 citations · Full text

, , +17

Identification of Paracaspases and Metacaspases Two Ancient Families of Caspase-like Proteins, One of which Plays a Key Role in MALT Lymphoma

Molecular Cell · 2000 · 454 citations

, , +15

1–5 of 225

Authors

1K

  1. GS
    Guy S. Salvesen

    Sanford Burnham Prebys Medical Discovery Institute, United States

    16 publications · 1.4K citations

    15

    h-index

  2. MG
    Markus G. Grütter

    University of Zurich, Switzerland

    9 publications · 482 citations

    9

    h-index

  3. PV
    Peter Vandenabeele

    Ghent University, Belgium

    8 publications · 949 citations

    8

    h-index

  4. DW
    Donald W. Nicholson

    Merck Canada Inc. (Canada), Canada

    8 publications · 1.8K citations

    8

    h-index

  5. WD
    Wim Declercq

    Ghent University, Belgium

    6 publications · 808 citations

    6

    h-index

1–5 of 1K

Institutions

312

  1. Sanford Burnham Prebys Medical Discovery Institute

    La Jolla, United States

    16 h-index

    62 publications

    10.6K citations

  2. Vlaams Instituut voor Biotechnologie

    Ghent, Belgium

    10 h-index

    67 publications

    9.9K citations

  3. University of Zurich

    Zurich, Switzerland

    9 h-index

    53 publications

    2.6K citations

  4. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    8 h-index

    33 publications

    7.9K citations

  5. Kyoto University

    Kyoto, Japan

    7 h-index

    24 publications

    2.9K citations

  6. University of California, San Francisco

    San Francisco, United States

    7 h-index

    26 publications

    2.1K citations

  7. McGill University

    Montreal, Canada

    6 h-index

    24 publications

    2.2K citations

  8. Wrocław University of Science and Technology

    Wroclaw, Poland

    6 h-index

    12 publications

    622 citations

1–8 of 312

Venues

  1. Journal of Biological Chemistry

    JBC · 38 publications · 5.1K citations

    31

    h-index

  2. Cell Death and Differentiation

    CDD · 14 publications · 1.4K citations

    14

    h-index

  3. Biochemical Journal

    BJ · 13 publications · 1K citations

    12

    h-index

  4. Biochemical and Biophysical Research Communications

    BBRC · 6 publications · 206 citations

    6

    h-index

  5. Molecular Cell

    6 publications · 1.5K citations

    6

    h-index

1–5