Concepedia

Bioreductive Activation

Bioreductive Activation is a prodrug activation mechanism in which enzymatic reduction under hypoxic or low-redox conditions selectively converts an inactive prodrug into its active cytotoxic form, distinguishing it from other activation mechanisms by its reliance on cellular reductases and oxygen-sensitive biotransformation.

87

Publications

6.2K

Citations

403

Authors

125

Institutions

Publications per year

2017–2026

8

Parents

Publications

87

Nitro-Group-Containing Drugs

Kunal Nepali, Hsueh‐Yun Lee, Jing‐Ping Liou · Journal of Medicinal Chemistry · 2018 · 618 citations · Full text

, , +16

Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in <i>Mycobacterium tuberculosis</i>

Ujjini H. Manjunatha, Helena I. Boshoff, Cynthia S. Dowd et al. · Proceedings of the National Academy of Sciences · 2005 · 332 citations · Full text

, , +17

Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors

R Rampling, Garth Cruickshank, Alexander D. Lewis et al. · International Journal of Radiation Oncology*Biology*Physics · 1994 · 300 citations

, , +14

Potent and Highly Selective Hypoxia-Activated Achiral Phosphoramidate Mustards as Anticancer Drugs

Hailong Jiao, Jacob A. Kaizerman, Timothy F. Stanton et al. · Journal of Medicinal Chemistry · 2008 · 239 citations

, , +17

Reductase Enzyme Expression Across the National Cancer Institute Tumor Cell Line Panel: Correlation With Sensitivity to Mitomycin C and EO9

Sara A. Fitzsimmons, Paul Workman, Michael R. Grever et al. · JNCI Journal of the National Cancer Institute · 1996 · 235 citations · Full text

, , +17

1–5 of 87

Authors

403

  1. WR
    William R. Wilson

    University of Auckland, New Zealand

    7 publications · 438 citations

    7

    h-index

  2. RM
    Roger M. Phillips

    University of Bradford, United Kingdom

    7 publications · 235 citations

    7

    h-index

  3. WA
    William A. Denny

    University of Auckland, New Zealand

    7 publications · 317 citations

    7

    h-index

  4. DR
    David Ross

    University of Colorado Health, United States

    6 publications · 567 citations

    6

    h-index

  5. DS
    David Siegel

    University of Colorado Health, United States

    5 publications · 514 citations

    5

    h-index

1–5 of 403

Institutions

125

  1. University of Auckland

    Auckland, New Zealand

    12 h-index

    55 publications

    4.5K citations

  2. Cancer Society of New Zealand

    Wellington, New Zealand

    7 h-index

    45 publications

    4K citations

  3. University of Colorado Health

    Aurora, United States

    5 h-index

    5 publications

    514 citations

  4. Cancer Research UK

    London, United Kingdom

    4 h-index

    17 publications

    776 citations

  5. University of Bradford

    Bradford, United Kingdom

    4 h-index

    17 publications

    522 citations

  6. Yale University

    New Haven, United States

    4 h-index

    17 publications

    887 citations

  7. University of Missouri

    Columbia, United States

    3 h-index

    17 publications

    714 citations

  8. Maurice Wilkins Centre

    Auckland, New Zealand

    3 h-index

    13 publications

    561 citations

1–8 of 125

Venues

  1. PubMed

    Repository · 18 publications · 1.1K citations

    16

    h-index

  2. Journal of Medicinal Chemistry

    7 publications · 1.1K citations

    7

    h-index

  3. British Journal of Cancer

    BJC · 5 publications · 261 citations

    5

    h-index

  4. Journal of the American Chemical Society

    JACS · 3 publications · 215 citations

    3

    h-index

  5. Biochemical Pharmacology

    3 publications · 154 citations

    3

    h-index

1–5