Concepedia

Bioprocess Scale-up

Bioprocess Scale-Up is an engineering methodology in bioprocess and fermentation engineering that systematically translates a bioprocess from laboratory or pilot scale to larger industrial scales by enlarging reactor volume and adapting equipment design and operating conditions so as to maintain or improve the established biological performance, product quality, and process robustness.

533

Publications

23.6K

Citations

2.1K

Authors

645

Institutions

Publications per year

2017–2026

199

Variants

Scale-up Of Bioprocesses

Parents

Children

Publications

533

Process-scale disruption of microorganisms

Anton P. J. Middelberg · Biotechnology Advances · 1995 · 456 citations

, , +12

Scale-up of industrial microbial processes

Jason S Crater, Jefferson C. Lievense · FEMS Microbiology Letters · 2018 · 263 citations · Full text

, , +17

Scale-up methodologies for Escherichia coli and yeast fermentation processes

Beth Junker · Journal of Bioscience and Bioengineering · 2004 · 230 citations

, , +16

Scale‐up analysis for a CHO cell culture process in large‐scale bioreactors

Zizhuo Xing, Brian Kenty, Zheng Jian Li et al. · Biotechnology and Bioengineering · 2009 · 224 citations

, , +17

Scale-up strategies for solid state fermentation systems

B. K. Lonsane, Gerardo Saucedo‐Castañeda, Maurice Raimbault et al. · Process Biochemistry · 1992 · 206 citations

, , +14

1–5 of 533

Authors

2.1K

  1. PN
    Peter Neubauer

    Technische Universität Berlin, Germany

    9 publications · 411 citations

    9

    h-index

  2. AW
    Alvin W. Nienow

    University of Birmingham, United Kingdom

    7 publications · 343 citations

    7

    h-index

  3. NJ
    Nigel J. Titchener‐Hooker

    University College London, United Kingdom

    6 publications · 198 citations

    6

    h-index

  4. JB
    Jochen Büchs

    RWTH Aachen University, Germany

    6 publications · 502 citations

    6

    h-index

  5. HN
    Henk Noorman

    DSM (Netherlands), Netherlands

    5 publications · 420 citations

    5

    h-index

1–5 of 2.1K

Institutions

645

  1. University College London

    London, United Kingdom

    20 h-index

    75 publications

    2.6K citations

  2. Biochemical Society

    London, United Kingdom

    16 h-index

    58 publications

    2K citations

  3. Technische Universität Berlin

    Berlin, Germany

    11 h-index

    38 publications

    1.8K citations

  4. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    10 h-index

    46 publications

    2K citations

  5. Delft University of Technology

    Delft, The Netherlands

    9 h-index

    21 publications

    1.6K citations

  6. RWTH Aachen University

    Aachen, Germany

    9 h-index

    33 publications

    2.8K citations

  7. Technical University of Denmark

    Kongens Lyngby, Denmark

    9 h-index

    36 publications

    2.3K citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    27 publications

    1.5K citations

1–8 of 645

Venues

  1. Biotechnology and Bioengineering

    59 publications · 3.1K citations

    37

    h-index

  2. Bioresource Technology

    27 publications · 1.8K citations

    22

    h-index

  3. Biotechnology Progress

    24 publications · 994 citations

    18

    h-index

  4. Biochemical Engineering Journal

    BEJ · 16 publications · 558 citations

    15

    h-index

  5. Chemical Engineering Science

    14 publications · 629 citations

    13

    h-index

1–5