Concepedia

Biliary Excretion Variability

Biliary Excretion Variability is a physiological construct that denotes the degree of fluctuation in the hepatobiliary transport and elimination of xenobiotics or endogenous compounds across individuals, populations, or experimental conditions, distinguished by its dependence on biochemical, genetic, and environmental factors influencing bile-mediated clearance mechanisms.

21

Publications

1.3K

Citations

72

Authors

29

Institutions

Publications per year

2017–2026

0

Parents

Publications

21

Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.

Lalitha Iyer, Christopher D. King, P. F. Whitington et al. · Journal of Clinical Investigation · 1998 · 680 citations · Full text

, , +17

Biliary excretion of colchicine.

A L Hunter, Curtis D. Klaassen · Journal of Pharmacology and Experimental Therapeutics · 1975 · 90 citations

, , +16

Species variations in the biliary and urinary excretion of arsenate, arsenite and their metabolites

Iván L. Csanaky, Zoltán Gregus · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · 2002 · 67 citations

, , +14

Ethnic Variability in the Expression of Hepatic Drug Transporters: Absolute Quantification by an Optimized Targeted Quantitative Proteomic Approach

Kuan‐Wei Peng, James A. Bacon, Ming Zheng et al. · Drug Metabolism and Disposition · 2015 · 57 citations

, , +17

Interspecies Scaling of Biliary Excreted Drugs: A Comparison of Several Methods**The views expressed in this article are those of the author and do not reflect the official policy of the FDA. No official support or endorsement by the FDA is intended or should be inferred.

Iftekhar Mahmood · Journal of Pharmaceutical Sciences · 2005 · 48 citations

, , +17

1–5 of 21

Authors

72

  1. ZG
    Zoltán Gregus

    University of Pecs, Hungary

    2 publications · 96 citations

    2

    h-index

  2. CD
    Curtis D. Klaassen

    University of Kansas Medical Center, United States

    2 publications · 119 citations

    2

    h-index

  3. RL
    Roger L. Priore

    University at Buffalo, State University of New York, United States

    1 publications · 13 citations

    1

    h-index

  4. KP
    Kuan‐Wei Peng

    University of Kansas, United States

    1 publications · 57 citations

    1

    h-index

  5. EK
    Eiji Kobayashi

    Jichi Medical University, Japan

    1 publications · 11 citations

    1

    h-index

1–5 of 72

Institutions

29

  1. Eli Lilly (United States)

    Indianapolis, United States

    2 h-index

    7 publications

    367 citations

  2. Karolinska Institutet

    Stockholm, Sweden

    2 h-index

    4 publications

    57 citations

  3. University of Iowa

    Iowa City, United States

    1 h-index

    4 publications

    2.7K citations

  4. Roswell Park Comprehensive Cancer Center

    Buffalo, United States

    1 h-index

    3 publications

    39 citations

  5. National Institutes of Health

    Bethesda, United States

    1 h-index

    2 publications

    88 citations

  6. Center for Drug Evaluation and Research

    Silver Spring, United States

    1 h-index

    1 publications

    48 citations

  7. Arc Research Institute

    Palo Alto, United States

    1 h-index

    3 publications

    60 citations

  8. University of Pittsburgh

    Pittsburgh, United States

    1 h-index

    3 publications

    48 citations

1–8 of 29

Venues

  1. Xenobiotica

    3 publications · 82 citations

    3

    h-index

  2. PubMed

    Repository · 2 publications · 49 citations

    2

    h-index

  3. Antimicrobial Agents and Chemotherapy

    AAC · 2 publications · 55 citations

    2

    h-index

  4. Journal of Clinical Investigation

    JCI · 1 publications · 680 citations

    1

    h-index

  5. Research in Veterinary Science

    1 publications · 20 citations

    1

    h-index

1–5