Concepedia

Biased Signaling

Biased Signaling is a phenomenon in G protein-coupled receptor pharmacology where a ligand preferentially activates a specific intracellular signaling pathway relative to others downstream of the same receptor, thereby diverging from balanced agonism across multiple transduction mechanisms.

138

Publications

9.5K

Citations

989

Authors

296

Institutions

Publications per year

2017–2026

79

Variants

Ligand Bias

Parents

Publications

138

Biased Signaling Pathways in β <sub>2</sub> -Adrenergic Receptor Characterized by <sup>19</sup> F-NMR

Jeffrey J. Liu, Reto Horst, Vsevolod Katritch et al. · Science · 2012 · 696 citations · Full text

, , +17

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

Francis S. Willard, Jonathan D. Douros, M Gabe et al. · JCI Insight · 2020 · 487 citations · Full text

, , +17

Quantifying Ligand Bias at Seven-Transmembrane Receptors

Sudarshan Rajagopal, Seungkirl Ahn, David H. Rominger et al. · Molecular Pharmacology · 2011 · 390 citations

, , +17

The role of kinetic context in apparent biased agonism at GPCRs

Carmen Klein Herenbrink, David A. Sykes, Prashant Donthamsetti et al. · Nature Communications · 2016 · 337 citations · Full text

, , +17

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

Denise Wootten, John Simms, Laurence J. Miller et al. · Proceedings of the National Academy of Sciences · 2013 · 254 citations

, , +17

1–5 of 138

Authors

989

  1. AC
    Arthur Christopoulos

    Monash University, Australia

    9 publications · 1.2K citations

    9

    h-index

  2. PM
    Patrick M. Sexton

    Monash University, Australia

    9 publications · 1.2K citations

    9

    h-index

  3. MB
    Michel Bouvier

    Université de Montréal, Canada

    8 publications · 639 citations

    8

    h-index

  4. SR
    Sudarshan Rajagopal

    Duke Medical Center, United States

    7 publications · 796 citations

    7

    h-index

  5. RJ
    Robert J. Lefkowitz

    Duke Medical Center, United States

    5 publications · 1.1K citations

    5

    h-index

1–5 of 989

Institutions

296

  1. Duke Medical Center

    Durham, United States

    14 h-index

    53 publications

    5.3K citations

  2. Duke University

    Durham, United States

    13 h-index

    46 publications

    5.3K citations

  3. Monash University

    Melbourne, Australia

    12 h-index

    86 publications

    8.9K citations

  4. Duke University Hospital

    Durham, United States

    11 h-index

    44 publications

    4.4K citations

  5. University of Copenhagen

    Copenhagen, Denmark

    9 h-index

    59 publications

    5.2K citations

  6. Institute for Research in Immunology and Cancer

    Montreal, Canada

    7 h-index

    25 publications

    2.3K citations

  7. Université de Montréal

    Montreal, Canada

    7 h-index

    20 publications

    1.7K citations

  8. Harvard University

    Cambridge, United States

    6 h-index

    21 publications

    2.1K citations

1–8 of 296

Venues

  1. Molecular Pharmacology

    12 publications · 1.1K citations

    12

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 11 publications · 1.1K citations

    11

    h-index

  3. Science Signaling

    7 publications · 513 citations

    7

    h-index

  4. Journal of Biological Chemistry

    JBC · 7 publications · 484 citations

    7

    h-index

  5. Journal of Medicinal Chemistry

    6 publications · 197 citations

    6

    h-index

1–5