Concepedia

Benzene Ring Replacement

Benzene Ring Replacement is a chemical modification strategy in medicinal chemistry wherein a benzene ring in a bioactive molecule is substituted with a heterocyclic or aliphatic ring system to optimize pharmacological properties while maintaining structural similarity and biological activity.

241

Publications

9.4K

Citations

1.1K

Authors

341

Institutions

Publications per year

2017–2026

44

Parents

Publications

241

Antioxidant Effects of Some Ginger Constituents

Hiroe Kikuzaki, Nobuji Nakatani · Journal of Food Science · 1993 · 722 citations

, , +17

Variable Pore Size, Variable Chemical Functionality, and an Example of Reactivity within Porous Phenylacetylene Silver Salts

Y.-H. Kiang, Geoffrey B. Gardner, Stephen Lee et al. · Journal of the American Chemical Society · 1999 · 218 citations

, , +17

Saturated Bioisosteres of <i>ortho</i>‐Substituted Benzenes

Aleksandr Denisenko, Pavel Garbuz, Svitlana V. Shishkina et al. · Angewandte Chemie International Edition · 2020 · 208 citations

, , +14

Identification and Characterization of Novel Benzil (Diphenylethane-1,2-dione) Analogues as Inhibitors of Mammalian Carboxylesterases

Randy M. Wadkins, Janice L. Hyatt, Xin Wei et al. · Journal of Medicinal Chemistry · 2005 · 186 citations · Full text

, , +17

Tetraphenylbenziporphyrin—A Ligand for Organometallic Chemistry

Marcin Stępień, Lechosław Latos‐Grażyński · Chemistry - A European Journal · 2001 · 171 citations · Full text

, , +13

1–5 of 241

Authors

1.1K

  1. LL
    Lechosław Latos‐Grażyński

    University of Wrocław, Poland

    3 publications · 256 citations

    3

    h-index

  2. YF
    Y. Fulmer Shealy

    Southern Research Institute, United States

    3 publications · 36 citations

    3

    h-index

  3. FL
    Feng Liu

    China Agricultural University, China

    2 publications · 31 citations

    2

    h-index

  4. TH
    Teng He

    Dalian Institute of Chemical Physics, China

    2 publications · 49 citations

    2

    h-index

  5. AK
    Abhijeet Karkamkar

    Pacific Northwest National Laboratory, United States

    2 publications · 49 citations

    2

    h-index

1–5 of 1.1K

Institutions

341

  1. Kyoto University

    Kyoto, Japan

    7 h-index

    27 publications

    1.3K citations

  2. Chinese Academy of Sciences

    Beijing, China

    6 h-index

    16 publications

    464 citations

  3. Imperial College London

    London, United Kingdom

    4 h-index

    13 publications

    876 citations

  4. Cairo University

    Giza, Egypt

    3 h-index

    6 publications

    90 citations

  5. Cardiff University

    Cardiff, United Kingdom

    3 h-index

    14 publications

    754 citations

  6. University of Wrocław

    Wroclaw, Poland

    3 h-index

    10 publications

    682 citations

  7. Tokyo Institute of Technology

    Tokyo, Japan

    3 h-index

    9 publications

    288 citations

  8. University of Warsaw

    Warsaw, Poland

    3 h-index

    9 publications

    338 citations

1–8 of 341

Venues

  1. Journal of Medicinal Chemistry

    18 publications · 1.1K citations

    15

    h-index

  2. Liquid Crystals

    10 publications · 209 citations

    10

    h-index

  3. Chemical and Pharmaceutical Bulletin

    10 publications · 222 citations

    10

    h-index

  4. Journal of the American Chemical Society

    JACS · 7 publications · 537 citations

    7

    h-index

  5. European Journal of Medicinal Chemistry

    7 publications · 224 citations

    7

    h-index

1–5