Janice L. Hyatt

Identification and Characterization of Novel Benzil (Diphenylethane-1,2-dione) Analogues as Inhibitors of Mammalian Carboxylesterases

Randy M. Wadkins, Janice L. Hyatt, Xin Wei et al. · Journal of Medicinal Chemistry · 2005 · 186 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Crystal Structure of Human Carboxylesterase 1 Complexed with the Alzheimer's Drug Tacrine

Sompop Bencharit, Christopher L. Morton, Janice L. Hyatt et al. · Chemistry & Biology · 2003 · 173 citations · Full text

Life Sciences, Biochemistry, Pharmacology +12

Structural Insights into Drug Processing by Human Carboxylesterase 1: Tamoxifen, Mevastatin, and Inhibition by Benzil

Christopher D. Fleming, Sompop Bencharit, Carol C. Edwards et al. · Journal of Molecular Biology · 2005 · 144 citations

Medicine, Biochemistry, Pharmacology +13

Discovery of Novel Selective Inhibitors of Human Intestinal Carboxylesterase for the Amelioration of Irinotecan-Induced Diarrhea: Synthesis, Quantitative Structure-Activity Relationship Analysis, and Biological Activity

Randy M. Wadkins, Janice L. Hyatt, Kyoung Jin P. Yoon et al. · Molecular Pharmacology · 2004 · 95 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Brain Tumor Oncolysis with Replication-Conditional Herpes Simplex Virus Type 1 Expressing the Prodrug-Activating Genes, <i>CYP2B1</i> and <i>Secreted Human Intestinal Carboxylesterase</i>, in Combination with Cyclophosphamide and Irinotecan

Edyta Tyminski, Stanley G. LeRoy, Kinya Terada et al. · Cancer Research · 2005 · 94 citations

Medicine, Oncology, Pharmacology +17