Concepedia

Backbone Remodeling

Backbone Remodeling is a protein engineering strategy that involves the structural modification of a protein scaffold’s secondary and tertiary framework to alter its conformational stability, functional properties, or suitability for functional site integration while preserving its overall fold or core architecture.

29

Publications

2.3K

Citations

148

Authors

58

Institutions

Publications per year

2017–2026

8

Parents

Publications

29

Meta R-CNN: Towards General Solver for Instance-Level Low-Shot Learning

Xiaopeng Yan, Ziliang Chen, Anni Xu et al. · 2019 · 611 citations

, , +14

Increased Diels-Alderase activity through backbone remodeling guided by Foldit players

Christopher B. Eiben, Justin B. Siegel, Jacob B. Bale et al. · Nature Biotechnology · 2012 · 316 citations

, , +14

Complete sequence of the IncPβ plasmid R751: implications for evolution and organisation of the IncP backbone

Peter B. Thorsted, Donia Macartney‐Coxson, Parveen Akhtar et al. · Journal of Molecular Biology · 1998 · 217 citations

, , +16

A Polymer with “Locked” Degradability: Superior Backbone Stability and Accessible Degradability Enabled by Mechanophore Installation

Tze‐Gang Hsu, Junfeng Zhou, Hsin‐Wei Su et al. · Journal of the American Chemical Society · 2020 · 164 citations

, , +16

Using halogen bonds to address the protein backbone: a systematic evaluation

Rainer Wilcken, Markus O. Zimmermann, Andreas Lange et al. · Journal of Computer-Aided Molecular Design · 2012 · 101 citations

, , +14

1–5 of 29

Authors

148

  1. JW
    James W. Canary

    New York University, United States

    2 publications · 40 citations

    2

    h-index

  2. XW
    Xiaojian Wang

    Nanjing Tech University, China

    2 publications · 40 citations

    2

    h-index

  3. PS
    Paramjit S. Arora

    New York University, United States

    2 publications · 40 citations

    2

    h-index

  4. DB
    David Baker

    University of Washington, United States

    2 publications · 339 citations

    2

    h-index

  5. WP
    Werner Pansegrau

    Max Planck Institute for Molecular Genetics, Germany

    2 publications · 242 citations

    2

    h-index

1–5 of 148

Institutions

58

  1. Fred Hutch Cancer Center

    Seattle, United States

    3 h-index

    9 publications

    1K citations

  2. University of Washington

    Seattle, United States

    3 h-index

    19 publications

    2.9K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    3 publications

    395 citations

  4. Max Planck Institute for Molecular Genetics

    Berlin, Germany

    2 h-index

    3 publications

    267 citations

  5. New York University

    New York, United States

    2 h-index

    8 publications

    160 citations

  6. Seoul National University

    Seoul, South Korea

    1 h-index

    4 publications

    200 citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    1 h-index

    2 publications

    44 citations

  8. Wuhan University

    Wuhan, China

    1 h-index

    3 publications

    129 citations

1–8 of 58

Venues

  1. 3

    h-index

  2. Journal of Molecular Biology

    JMB · 2 publications · 280 citations

    2

    h-index

  3. Journal of the American Chemical Society

    JACS · 2 publications · 179 citations

    2

    h-index

  4. Nature Biotechnology

    1 publications · 316 citations

    1

    h-index

  5. FEBS Journal

    1 publications · 24 citations

    1

    h-index

1–5