Concepedia

Autophagy-lysosome Dysfunction

Autophagy-Lysosome Dysfunction is a pathophysiological mechanism within the autophagy-lysosome pathway characterized by the impaired degradation and clearance of cellular substrates due to disruptions in autophagosome formation, lysosomal function, or their fusion, leading to the accumulation of toxic protein aggregates and damaged organelles in neurodegenerative diseases.

599

Publications

51.8K

Citations

4.5K

Authors

1.2K

Institutions

Publications per year

2017–2026

325

Variants

Autophagic-lysosomal Dysfunction

Parents

Publications

599

α-Synuclein Locus Triplication Causes Parkinson's Disease

Andrew Singleton, Matthew J. Farrer, Janel Johnson et al. · Science · 2003 · 4.4K citations

, , +15

The role of autophagy in neurodegenerative disease

Ralph A. Nixon · Nature Medicine · 2013 · 2K citations

, , +12

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

Ju‐Hyun Lee, Wai Haung Yu, Asok Kumar et al. · Cell · 2010 · 1.2K citations · Full text

, , +16

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice

Fiona Pickford, Eliezer Masliah, Markus Britschgi et al. · Journal of Clinical Investigation · 2008 · 1.1K citations

, , +17

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

Marta Martínez‐Vicente, Zsolt Tallóczy, Esther Wong et al. · Nature Neuroscience · 2010 · 858 citations · Full text

, , +14

1–5 of 599

Authors

4.5K

  1. AB
    Andrea Ballabio

    Telethon Institute Of Genetics And Medicine, Italy

    10 publications · 1.5K citations

    10

    h-index

  2. DC
    David C. Rubinsztein

    University of Cambridge, United Kingdom

    9 publications · 2.5K citations

    9

    h-index

  3. NR
    Nina Raben

    National Institute of Arthritis and Musculoskeletal and Skin Diseases, United States

    8 publications · 846 citations

    8

    h-index

  4. RA
    Ralph A. Nixon

    Nathan Kline Institute for Psychiatric Research, United States

    8 publications · 3.8K citations

    8

    h-index

  5. AD
    Abhinav Diwan

    Washington University in St. Louis, United States

    6 publications · 914 citations

    6

    h-index

1–5 of 4.5K

Institutions

1.2K

  1. National Institutes of Health

    Bethesda, United States

    25 h-index

    141 publications

    118.4K citations

  2. University College London

    London, United Kingdom

    18 h-index

    75 publications

    7.6K citations

  3. Harvard University

    Cambridge, United States

    16 h-index

    56 publications

    6K citations

  4. Soochow University

    Suzhou, China

    15 h-index

    98 publications

    5.2K citations

  5. Inserm

    Paris, France

    14 h-index

    89 publications

    4K citations

  6. Telethon Institute Of Genetics And Medicine

    Naples, Italy

    14 h-index

    43 publications

    7.1K citations

  7. Albert Einstein College of Medicine

    Bronx, United States

    12 h-index

    40 publications

    12.8K citations

  8. Chinese Academy of Sciences

    Beijing, China

    12 h-index

    61 publications

    3.6K citations

1–8 of 1.2K

Venues

  1. Autophagy

    82 publications · 5.3K citations

    45

    h-index

  2. Human Molecular Genetics

    23 publications · 3.1K citations

    20

    h-index

  3. Cell Death and Disease

    17 publications · 1.1K citations

    17

    h-index

  4. Scientific Reports

    15 publications · 647 citations

    15

    h-index

  5. PLoS ONE

    11 publications · 1.2K citations

    11

    h-index

1–5