Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

Yukihiro Kabeya · The EMBO Journal · 2000 · 6.5K citations · Full text

Cell Autophagy, Autophagosome Membranes, Autophagy +9

Autophagy fights disease through cellular self-digestion

Noboru Mizushima, Beth Levine, Ana María Cuervo et al. · Nature · 2008 · 6.4K citations · Full text

Cell Autophagy, Mitophagy, Autoimmune Disease +8

Autophagy regulates lipid metabolism

Rajat Singh, Susmita Kaushik, Yongjun Wang et al. · Nature · 2009 · 3.8K citations · Full text

Cell Autophagy, Mitophagy, Lipid Metabolism +7

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

Gilad Twig, Álvaro A. Elorza, Anthony Molina et al. · The EMBO Journal · 2008 · 3K citations · Full text

Biology, Cell Autophagy, Mitophagy +10

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Brinda Ravikumar, Zdenek Berger, J. Eric Davies et al. · Nature Genetics · 2004 · 2.3K citations · Full text

Cell Autophagy, Mitophagy, Medicine +9