Concepedia

Autoinflammatory Mechanisms

Autoinflammatory Mechanisms is a pathophysiological construct that refers to the dysregulated innate immune system activity characterized by spontaneous inflammation without high-titer autoantibodies or antigen-specific T cells, primarily mediated through aberrant cytokine signaling, inflammasome activation, and neutrophil hyperreactivity, distinguishing it from classical autoimmune and infectious etiologies in the context of pediatric Behçet disease.

539

Publications

44K

Citations

4K

Authors

1.2K

Institutions

Publications per year

2017–2026

286

Parents

Publications

539

NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

Laetitia Agostini, Fabio Martinon, Kimberly Burns et al. · Immunity · 2004 · 1.7K citations · Full text

, , +15

Germline Mutations in the Extracellular Domains of the 55 kDa TNF Receptor, TNFR1, Define a Family of Dominantly Inherited Autoinflammatory Syndromes

Michael McDermott, Ivona Aksentijevich, Jérôme Galon et al. · Cell · 1999 · 1.4K citations · Full text

, , +17

Activated STING in a Vascular and Pulmonary Syndrome

Adriana A. de Jesus, Bernadette Marrero, Dan Yang et al. · New England Journal of Medicine · 2014 · 1.4K citations · Full text

, , +14

Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition

Raphaela Goldbach‐Mansky, Natalie Dailey Garnes, Scott Canna et al. · New England Journal of Medicine · 2006 · 903 citations · Full text

, , +17

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

Min Peng, Na Yin, Sagar Chhangawala et al. · Science · 2016 · 773 citations · Full text

, , +17

1–5 of 539

Authors

4K

  1. DL
    Daniel L. Kastner

    National Institute of Arthritis and Musculoskeletal and Skin Diseases, United States

    24 publications · 8.9K citations

    24

    h-index

  2. MG
    Marco Gattorno

    Istituto Giannina Gaslini, Italy

    22 publications · 2.7K citations

    19

    h-index

  3. IA
    Ivona Aksentijevich

    National Human Genome Research Institute, United States

    16 publications · 5.3K citations

    15

    h-index

  4. HJ
    Helen J. Lachmann

    University College London, United Kingdom

    13 publications · 2.5K citations

    13

    h-index

  5. HM
    Hal M. Hoffman

    University of California San Diego, United States

    12 publications · 2.6K citations

    12

    h-index

1–5 of 4K

Institutions

1.2K

  1. National Institutes of Health

    Bethesda, United States

    26 h-index

    199 publications

    44.2K citations

  2. National Institute of Arthritis and Musculoskeletal and Skin Diseases

    Bethesda, United States

    25 h-index

    179 publications

    124.3K citations

  3. University College London

    London, United Kingdom

    23 h-index

    78 publications

    11.8K citations

  4. Inserm

    Paris, France

    20 h-index

    103 publications

    7.8K citations

  5. Istituto Giannina Gaslini

    Genoa, Italy

    20 h-index

    74 publications

    9.3K citations

  6. National Human Genome Research Institute

    Bethesda, United States

    19 h-index

    112 publications

    27.3K citations

  7. Charité - Universitätsmedizin Berlin

    Berlin, Germany

    17 h-index

    49 publications

    3.9K citations

  8. Istituti di Ricovero e Cura a Carattere Scientifico

    Rome, Italy

    16 h-index

    76 publications

    5.2K citations

1–8 of 1.2K

Venues

  1. Frontiers in Immunology

    26 publications · 875 citations

    21

    h-index

  2. PubMed

    Repository · 34 publications · 1K citations

    20

    h-index

  3. Arthritis & Rheumatism

    19 publications · 2.8K citations

    19

    h-index

  4. Pediatric Rheumatology

    PROJ · 15 publications · 828 citations

    15

    h-index

  5. Annals of the Rheumatic Diseases

    ARD · 14 publications · 1.2K citations

    14

    h-index

1–5