Activated STING in a Vascular and Pulmonary Syndrome

Adriana A. de Jesus, Bernadette Marrero, Dan Yang, +42

New England Journal of Medicine

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

Scott Canna, Adriana A. de Jesus, Sushanth Gouni, +20

Nature Genetics

InflammationImmune Cell DevelopmentMedicineImmunologyChronic Inflammation +8

Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production

Anja Brehm, Yin Liu, Afzal Sheikh, +40

Journal of Clinical Investigation

GeneticsImmunodeficienciesImmunologyProteasomeMolecular Biology +24

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

David Olagnier, Aske M. Brandtoft, Camilla Gunderstofte, +31

Nature Communications

Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases

Adriana A. de Jesus, Yangfeng Hou, Stephen R. Brooks, +84

Journal of Clinical Investigation

Inflammatory Lung DiseaseChronic InterferonLung InflammationImmunodeficienciesImmunology +20

STAT3 Protein Interacts with Class O Forkhead Transcription Factors in the Cytoplasm and Regulates Nuclear/Cytoplasmic Localization of FoxO1 and FoxO3a Proteins in CD4+ T Cells

Hyun‐Mee Oh, Cheng‐Rong Yu, Ivy M. Dambuza, +2

Journal of Biological Chemistry

Inactive Pfoxo1T-regulatory CellImmunologyImmune RegulationImmunologic Mechanism +22

Regression of subcutaneous B16 melanoma tumors after intratumoral delivery of an IL-15-expressing plasmid followed by in vivo electroporation

Kenneth E. Ugen, Michele A. Kutzler, Bernadette Marrero, +4

Cancer Gene Therapy

Vivo ElectroporationIntratumoral DeliverySkin CancerMelanomaImmunology +8

Generation of a tumor spheroid in a microgravity environment as a 3D model of melanoma

Bernadette Marrero, Jane L. Messina, Richard Heller

In Vitro Cellular & Developmental Biology - Animal

EngineeringMedicineMelanomaBiological MicroenvironmentsMicrogravity Environment +5

The use of an in vitro 3D melanoma model to predict in vivo plasmid transfection using electroporation

Bernadette Marrero, Richard Heller

Biomaterials

Tissue EngineeringVitro 3DEngineeringMedicineMelanoma +8

Interleukin 27 Induces the Expression of Complement Factor H (CFH) in the Retina

Ahjoku Amadi‐Obi, Cheng‐Rong Yu, Ivy M. Dambuza, +3

PLoS ONE

InflammationCytokineComplement SystemSignal TransductionAutoimmune Disease +12