SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

David Olagnier, Ensieh Farahani, Jacob Thyrsted, +35

Nature Communications

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling

Anne Louise Hansen, Gregory J. Buchan, Michael Rühl, +26

Proceedings of the National Academy of Sciences

ImmunologyPathologyInflammationAntiviral Drug DevelopmentSting Palmitoylation +16

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

David Olagnier, Aske M. Brandtoft, Camilla Gunderstofte, +31

Nature Communications

Cellular Oxidative Stress Response Controls the Antiviral and Apoptotic Programs in Dengue Virus-Infected Dendritic Cells

David Olagnier, Suraj Peri, Courtney Steel, +9

PLoS Pathogens

Dengue VirusInnate Immune SystemViral PathogenesisImmunologyCell Death +19

Global analyses revealed age‐related alterations in innate immune responses after stimulation of pathogen recognition receptors

Talibah Metcalf, Rafael Cubas, Khader Ghneim, +12

Aging Cell

Adaptive Immune SystemInnate Immune SystemImmunologyImmune RegulationImmune Aging +19

Host Restriction Factor SAMHD1 Limits Human T Cell Leukemia Virus Type 1 Infection of Monocytes via STING-Mediated Apoptosis

Alexandre Sze, S. Mehdi Belgnaoui, David Olagnier, +3

Cell Host & Microbe

Host ResponseAutoimmune DiseasePathogenesisImmunologyAutoimmunity +4

STEEP mediates STING ER exit and activation of signaling

Bao‐cun Zhang, Ramya Nandakumar, Line S. Reinert, +28

Nature Immunology

Signal TransductionIntercellular CommunicationCellular BiochemistryMedicineCell Biology +2

In Vitro and In Vivo Properties of Ellagic Acid in Malaria Treatment

Patrice Njomnang Soh, Benoît Witkowski, David Olagnier, +4

Antimicrobial Agents and Chemotherapy

Plasmodium Falciparum StrainsBiochemistryAntiparasitic AgentMedicineMalaria +11

The C-type Lectin Receptors Dectin-1, MR, and SIGNR3 Contribute Both Positively and Negatively to the Macrophage Response to Leishmania infantum

Lise Lefèvre, Geanncarlo Lugo‐Villarino, Étienne Meunier, +11

Immunity

InflammationParasitic ProtozoaLeishmania InfantumPathogenesisImmunology +8

Inhibition of Dengue and Chikungunya Virus Infections by RIG-I-Mediated Type I Interferon-Independent Stimulation of the Innate Antiviral Response

David Olagnier, Florine E. M. Scholte, Cindy Chiang, +7

Journal of Virology