Concepedia

Antigen-binding Fragments

Antigen-Binding Fragments is a class of engineered antibody derivatives comprising the minimal structural moiety of an immunoglobulin capable of specifically recognizing and binding to a designated antigenic epitope, distinguished from full-length antibodies by the absence of the crystallizable fragment (Fc) region and reduced molecular size while retaining target specificity.

672

Publications

43K

Citations

3.6K

Authors

870

Institutions

Publications per year

2017–2026

113

Variants

FabFab Fragments

Parents

Publications

672

Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation

Don C. Wiley, Ian A. Wilson, J.J. Skehel · Nature · 1981 · 1.6K citations

, , +16

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

Marc K. Jenkins, R H Schwartz · The Journal of Experimental Medicine · 1987 · 1.2K citations · Full text

, , +17

<i>In vitro</i> selection and evolution of functional proteins by using ribosome display

Jozef Hanes, Andreas Plückthun · Proceedings of the National Academy of Sciences · 1997 · 1.1K citations · Full text

, , +15

Assembly of a Functional Immunoglobulin F <sub>v</sub> Fragment in <i>Escherichia coli</i>

Arne Skerra, Andreas Plückthun · Science · 1988 · 969 citations

, , +17

"Diabodies": small bivalent and bispecific antibody fragments.

Philipp Holliger, Teresa Di Prospero, Greg Winter · Proceedings of the National Academy of Sciences · 1993 · 875 citations · Full text

, , +17

1–5 of 672

Authors

3.6K

  1. SM
    Serge Muyldermans

    Vrije Universiteit Brussel, Belgium

    20 publications · 3.4K citations

    19

    h-index

  2. AP
    Andreas Plückthun

    University of Zurich, Switzerland

    17 publications · 3.6K citations

    16

    h-index

  3. AS
    Arne Skerra

    Technical University of Munich, Germany

    11 publications · 1.4K citations

    10

    h-index

  4. CV
    Cécile Vincke

    Vrije Universiteit Brussel, Belgium

    9 publications · 1.5K citations

    9

    h-index

  5. KT
    Kouhei Tsumoto

    The University of Tokyo, Japan

    9 publications · 295 citations

    9

    h-index

1–5 of 3.6K

Institutions

870

  1. Vrije Universiteit Brussel

    Brussels, Belgium

    23 h-index

    144 publications

    26.3K citations

  2. National Institutes of Health

    Bethesda, United States

    15 h-index

    132 publications

    17K citations

  3. Vlaams Instituut voor Biotechnologie

    Ghent, Belgium

    15 h-index

    73 publications

    16.1K citations

  4. National Cancer Institute

    Bethesda, United States

    14 h-index

    53 publications

    4K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    14 h-index

    77 publications

    3.4K citations

  6. University of Zurich

    Zurich, Switzerland

    13 h-index

    43 publications

    7K citations

  7. Scripps Research Institute

    San Diego, United States

    11 h-index

    36 publications

    3.2K citations

  8. The University of Tokyo

    Tokyo, Japan

    11 h-index

    40 publications

    1.7K citations

1–8 of 870

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 42 publications · 7.3K citations

    36

    h-index

  2. Journal of Biological Chemistry

    JBC · 39 publications · 2.5K citations

    26

    h-index

  3. PubMed

    Repository · 35 publications · 2.3K citations

    24

    h-index

  4. Protein Engineering Design and Selection

    PEDS · 23 publications · 1.4K citations

    17

    h-index

  5. mAbs

    24 publications · 1.2K citations

    16

    h-index

1–5