Concepedia

Alpha-synuclein Clearance

Alpha-Synuclein Clearance is a cellular process denoting the selective degradation and removal of alpha-synuclein proteins through autophagy pathways, distinguishing it from other proteolytic mechanisms by its reliance on lysosomal engulfment of aggregated or misfolded species.

262

Publications

33.9K

Citations

1.8K

Authors

541

Institutions

Publications per year

2017–2026

158

Parents

Publications

262

Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy

Ana María Cuervo, Leonidas Stefanis, Ross A. Fredenburg et al. · Science · 2004 · 2K citations

, , +17

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

Julie L. Webb, Brinda Ravikumar, Jane T. Atkins et al. · Journal of Biological Chemistry · 2003 · 1.4K citations · Full text

, , +17

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

Sangjune Kim, Seung‐Hwan Kwon, Tae‐In Kam et al. · Neuron · 2019 · 1.4K citations · Full text

, , +16

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

Wouter Peelaerts, Luc Bousset, Anke Van der Perren et al. · Nature · 2015 · 1.1K citations · Full text

, , +13

Trehalose, a Novel mTOR-independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and α-Synuclein

Sovan Sarkar, J. Eric Davies, Zebo Huang et al. · Journal of Biological Chemistry · 2006 · 1.1K citations · Full text

, , +17

1–5 of 262

Authors

1.8K

  1. EM
    Eliezer Masliah

    University of California San Diego, United States

    15 publications · 2.6K citations

    15

    h-index

  2. RM
    Ronald Melki

    Centre National de la Recherche Scientifique, France

    11 publications · 3.2K citations

    11

    h-index

  3. ER
    Edward Rockenstein

    University of California San Diego, United States

    11 publications · 2K citations

    11

    h-index

  4. TF
    Tiago F. Outeiro

    Universitätsmedizin Göttingen, Germany

    10 publications · 1.6K citations

    10

    h-index

  5. SL
    Seung‐Jae Lee

    Konkuk University, South Korea

    9 publications · 2.1K citations

    9

    h-index

1–5 of 1.8K

Institutions

541

  1. University of California San Diego

    San Diego, United States

    15 h-index

    78 publications

    14.3K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    10 h-index

    38 publications

    7.2K citations

  3. Soochow University

    Suzhou, China

    10 h-index

    86 publications

    4.3K citations

  4. Second Affiliated Hospital of Soochow University

    Suzhou, China

    9 h-index

    55 publications

    2.7K citations

  5. Universitätsmedizin Göttingen

    Göttingen, Germany

    9 h-index

    13 publications

    1.7K citations

  6. Konkuk University

    Seoul, South Korea

    8 h-index

    28 publications

    7.5K citations

  7. Universidade Nova de Lisboa

    Lisbon, Portugal

    8 h-index

    35 publications

    2.3K citations

  8. Harvard University

    Cambridge, United States

    8 h-index

    24 publications

    7.7K citations

1–8 of 541

Venues

  1. Journal of Biological Chemistry

    JBC · 16 publications · 5K citations

    16

    h-index

  2. Autophagy

    12 publications · 1.5K citations

    12

    h-index

  3. PLoS ONE

    11 publications · 1.6K citations

    11

    h-index

  4. Journal of Neurochemistry

    JNC · 9 publications · 603 citations

    9

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 9 publications · 1.3K citations

    9

    h-index

1–5