Concepedia

Allosteric Switching

Allosteric Switching is a regulatory mechanism in which the binding of a ligand at an allosteric site induces a conformational change in a macromolecule, thereby modulating its activity at a distinct functional site through long-range structural reorganization.

91

Publications

4.5K

Citations

431

Authors

164

Institutions

Publications per year

2017–2026

33

Parents

Publications

91

The Chaperonin ATPase Cycle: Mechanism of Allosteric Switching and Movements of Substrate-Binding Domains in GroEL

Alan M. Roseman, Shaoxia Chen, Helen White et al. · Cell · 1996 · 381 citations · Full text

, , +17

Reprogramming Control of an Allosteric Signaling Switch Through Modular Recombination

John E. Dueber, Brian J. Yeh, Kayam Chak et al. · Science · 2003 · 301 citations

, , +17

Dynamics of allosteric transitions in GroEL

Changbong Hyeon, George H. Lorimer, D. Thirumalai · Proceedings of the National Academy of Sciences · 2006 · 159 citations · Full text

, , +17

Allosteric Transinhibition by Specific Antagonists in CCR2/CXCR4 Heterodimers

Denis Sohy, Marc Parmentier, Jean–Yves Springael · Journal of Biological Chemistry · 2007 · 148 citations · Full text

, , +16

An inter‐dimer allosteric switch controls NMDA receptor activity

Jean‐Baptiste Esmenjaud, David Stroebel, Kelvin Chan et al. · The EMBO Journal · 2018 · 141 citations · Full text

, , +14

1–5 of 91

Authors

431

  1. AH
    Amnon Horovitz

    Weizmann Institute of Science, Israel

    3 publications · 60 citations

    3

    h-index

  2. MF
    Michael F. Dunn

    University of California, Riverside, United States

    3 publications · 130 citations

    3

    h-index

  3. XL
    Xiaoxia Lü

    Peking University, China

    2 publications · 52 citations

    2

    h-index

  4. SN
    Stewart N. Loh

    SUNY Upstate Medical University, United States

    2 publications · 107 citations

    2

    h-index

  5. KL
    Kendra L. Hailey

    University of California San Diego, United States

    2 publications · 48 citations

    2

    h-index

1–5 of 431

Institutions

164

  1. University of California San Diego

    San Diego, United States

    5 h-index

    15 publications

    518 citations

  2. University of California, Riverside

    Riverside, United States

    4 h-index

    15 publications

    559 citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    14 publications

    1.2K citations

  4. University of California, Berkeley

    Berkeley, United States

    3 h-index

    6 publications

    441 citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    6 publications

    502 citations

  6. University of California, San Francisco

    San Francisco, United States

    3 h-index

    21 publications

    1.7K citations

  7. Weizmann Institute of Science

    Rehovot, Israel

    3 h-index

    12 publications

    210 citations

  8. European Bioinformatics Institute

    Cambridge, United Kingdom

    2 h-index

    4 publications

    224 citations

1–8 of 164

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 12 publications · 642 citations

    12

    h-index

  2. Journal of Molecular Biology

    JMB · 9 publications · 363 citations

    8

    h-index

  3. Journal of Biological Chemistry

    JBC · 5 publications · 347 citations

    5

    h-index

  4. Biochemistry

    5 publications · 193 citations

    5

    h-index

  5. Nature Communications

    3 publications · 93 citations

    3

    h-index

1–5