Concepedia

Allele-specific Silencing

Allele-Specific Silencing is a gene silencing technique that selectively inhibits the expression of one allele of a gene while leaving the other allele unaffected, typically exploiting sequence differences such as single nucleotide polymorphisms to achieve allele-specific targeting.

69

Publications

5.4K

Citations

613

Authors

236

Institutions

Publications per year

2017–2026

15

Variants

Allele-specific Gene Silencing

Parents

Publications

69

The <i>Air</i> Noncoding RNA Epigenetically Silences Transcription by Targeting G9a to Chromatin

Takashi Nagano, Jennifer A. Mitchell, Lionel A. Sanz et al. · Science · 2008 · 909 citations

, , +17

Allele-specific silencing of dominant disease genes

Victor M. Miller, Haibin Xia, Ginger L. Marrs et al. · Proceedings of the National Academy of Sciences · 2003 · 399 citations · Full text

, , +17

Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs

Jiaxin Hu, Masayuki Matsui, Keith T. Gagnon et al. · Nature Biotechnology · 2009 · 240 citations · Full text

, , +14

Allele-Specific Silencing of Mutant <i>Myh6</i> Transcripts in Mice Suppresses Hypertrophic Cardiomyopathy

Jianming Jiang, Hiroko Wakimoto, Jonathan G. Seidman et al. · Science · 2013 · 229 citations · Full text

, , +15

Sustained effects of nonallele‐specific <i>Huntingtin</i> silencing

Valérie Drouet, Valérie Perrin, Raymonde Hässig et al. · Annals of Neurology · 2009 · 210 citations

, , +17

1–5 of 69

Authors

613

  1. ND
    Nicole Déglon

    Centre National de la Recherche Scientifique, France

    5 publications · 580 citations

    5

    h-index

  2. HH
    Hirohiko Hohjoh

    National Center of Neurology and Psychiatry, Japan

    4 publications · 135 citations

    4

    h-index

  3. PH
    Philippe Hantraye

    Commissariat à l'Énergie Atomique et aux Énergies Alternatives, France

    3 publications · 418 citations

    3

    h-index

  4. RH
    Raymonde Hässig

    Commissariat à l'Énergie Atomique et aux Énergies Alternatives, France

    3 publications · 418 citations

    3

    h-index

  5. GA
    Gwennaëlle Aurégan

    Centre National de la Recherche Scientifique, France

    3 publications · 418 citations

    3

    h-index

1–5 of 613

Institutions

236

  1. Harvard University

    Cambridge, United States

    6 h-index

    28 publications

    2.3K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    34 publications

    9.7K citations

  3. National Institutes of Health

    Bethesda, United States

    5 h-index

    12 publications

    819 citations

  4. National Center of Neurology and Psychiatry

    Tokyo, Japan

    4 h-index

    12 publications

    479 citations

  5. Uppsala University

    Uppsala, Sweden

    4 h-index

    16 publications

    913 citations

  6. University of Coimbra

    Coimbra, Portugal

    4 h-index

    15 publications

    1.6K citations

  7. Leiden University Medical Center

    Leiden, The Netherlands

    4 h-index

    15 publications

    739 citations

  8. Institute of Bioorganic Chemistry, Polish Academy of Sciences

    Poznan, Poland

    3 h-index

    11 publications

    319 citations

1–8 of 236

Venues

  1. PLoS ONE

    8 publications · 504 citations

    8

    h-index

  2. Molecular Therapy — Nucleic Acids

    4 publications · 239 citations

    4

    h-index

  3. Journal of Biological Chemistry

    JBC · 2 publications · 182 citations

    2

    h-index

  4. Oncotarget

    2 publications · 74 citations

    2

    h-index

  5. Nature Communications

    2 publications · 89 citations

    2

    h-index

1–5