Concepedia

Affinity Maturation Screening

Affinity Maturation Screening is a methodological framework in antibody discovery that systematically evaluates and selects antibodies with incrementally improved binding affinity through iterative rounds of mutation, selection, and functional assessment, distinguishing it from primary screening approaches by focusing specifically on the optimization of antigen-binding strength in already reactive antibody candidates.

26

Publications

2K

Citations

274

Authors

67

Institutions

Publications per year

2017–2026

11

Parents

Publications

26

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

Michael Schoof, Bryan Faust, Reuben A. Saunders et al. · Science · 2020 · 467 citations · Full text

, , +16

Efficient evolution of human antibodies from general protein language models

Brian Hie, Varun R. Shanker, Duo Xu et al. · Nature Biotechnology · 2023 · 450 citations · Full text

, , +14

Antibody affinity maturation using bacterial surface display

Patrick S. Daugherty, G. Chen, Mark Olsen et al. · Protein Engineering Design and Selection · 1998 · 197 citations

, , +17

Selection and affinity maturation of IgNAR variable domains targeting <i>Plasmodium falciparum</i> AMA1

Stewart D. Nuttall, Karen S. Humberstone, Usha V. Krishnan et al. · Proteins Structure Function and Bioinformatics · 2004 · 106 citations

, , +17

Impaired Antibody Affinity Maturation Process Characterizes a Subset of Patients with Common Variable Immunodeficiency

Delphine Bonhomme, Lennart Hammarström, D Webster et al. · The Journal of Immunology · 2000 · 82 citations · Full text

, , +16

1–5 of 26

Authors

274

  1. PS
    Peter S. Kim

    Whitehead Institute for Biomedical Research, United States

    2 publications · 479 citations

    2

    h-index

  2. JS
    Jörg Scheuermann

    ETH Zurich, Switzerland

    2 publications · 80 citations

    2

    h-index

  3. ST
    Shaogeng Tang

    Stanford University, United States

    2 publications · 479 citations

    2

    h-index

  4. DX
    Duo Xu

    University of California, Los Angeles, United States

    2 publications · 479 citations

    2

    h-index

  5. PA
    Payton A. Weidenbacher

    Stanford University, United States

    2 publications · 479 citations

    2

    h-index

1–5 of 274

Institutions

67

  1. Stanford University

    Stanford, United States

    3 h-index

    20 publications

    3.5K citations

  2. ETH Zurich

    Zurich, Switzerland

    3 h-index

    20 publications

    819 citations

  3. Merck KGaA, Darmstadt (Germany)

    Darmstadt, Germany

    2 h-index

    5 publications

    174 citations

  4. Stanford Medicine

    Stanford, United States

    2 h-index

    3 publications

    508 citations

  5. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    1 publications

    23 citations

  6. Technische Universität Darmstadt

    Darmstadt, Germany

    2 h-index

    8 publications

    252 citations

  7. Chan Zuckerberg Initiative (United States)

    Redwood City, United States

    2 h-index

    4 publications

    1.4K citations

  8. Philochem (Switzerland)

    Otelfingen, Switzerland

    2 h-index

    9 publications

    486 citations

1–8 of 67

Venues

  1. mAbs

    3 publications · 93 citations

    3

    h-index

  2. The Journal of Immunology

    JI · 2 publications · 149 citations

    2

    h-index

  3. Methods in molecular biology

    Book series · 1 publications · 12 citations

    2

    h-index

  4. Protein Engineering Design and Selection

    PEDS · 2 publications · 213 citations

    2

    h-index

  5. Bioconjugate Chemistry

    1 publications · 58 citations

    1

    h-index

1–5