Concepedia

Adherens Junction Dysfunction

Adherens Junction Dysfunction is a pathological alteration in the structural and functional integrity of adherens junctions, characterized by impaired cadherin-mediated cell-cell adhesion and associated cytoskeletal coupling, leading to compromised epithelial barrier stability.

277

Publications

17.2K

Citations

1.8K

Authors

549

Institutions

Publications per year

2017–2026

76

Parents

Publications

277

A presenilin‐1/γ‐secretase cleavage releases the E‐cadherin intracellular domain and regulates disassembly of adherens junctions

Philippe Marambaud · The EMBO Journal · 2002 · 680 citations · Full text

, , +16

Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast

Scott L. Kominsky, Pedram Argani, Dorian Korz et al. · Oncogene · 2003 · 443 citations

, , +16

<i>NF2</i> deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions

Dominique Lallemand, Marcello Curto, Ichiko Saotome et al. · Genes & Development · 2003 · 338 citations · Full text

, , +17

Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions.

Aldo Del Maschio, Adriana Zanetti, Monica Corada et al. · The Journal of Cell Biology · 1996 · 337 citations · Full text

, , +17

Anuria, Omphalocele, and Perinatal Lethality in Mice Lacking the Cd34-Related Protein Podocalyxin

Régis Doyonnas, David B. Kershaw, Christian Duhme et al. · The Journal of Experimental Medicine · 2001 · 336 citations · Full text

, , +13

1–5 of 277

Authors

1.8K

  1. MH
    Mehran Haidari

    The University of Texas Health Science Center at Houston, United States

    4 publications · 108 citations

    4

    h-index

  2. YC
    Ying Chen

    National Defense Medical Center, Taiwan

    4 publications · 113 citations

    4

    h-index

  3. JB
    Jürgen Behrens

    Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany

    4 publications · 433 citations

    4

    h-index

  4. SH
    Shih-Horng Huang

    National Taiwan University, Taiwan

    3 publications · 153 citations

    3

    h-index

  5. SW
    Seu‐Mei Wang

    National Taiwan University, Taiwan

    4 publications · 104 citations

    3

    h-index

1–5 of 1.8K

Institutions

549

  1. Johns Hopkins University

    Baltimore, United States

    12 h-index

    96 publications

    12.7K citations

  2. Johns Hopkins Medicine

    Baltimore, United States

    10 h-index

    61 publications

    7.5K citations

  3. Northwestern University

    Evanston, United States

    8 h-index

    22 publications

    976 citations

  4. Inserm

    Paris, France

    8 h-index

    52 publications

    6.6K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    59 publications

    5.1K citations

  6. University of Chicago

    Chicago, United States

    6 h-index

    21 publications

    989 citations

  7. National Taiwan University

    Taipei, Taiwan

    6 h-index

    28 publications

    1K citations

  8. University of Illinois Chicago

    Chicago, United States

    6 h-index

    31 publications

    4K citations

1–8 of 549

Venues

  1. PLoS ONE

    10 publications · 363 citations

    10

    h-index

  2. PubMed

    Repository · 8 publications · 399 citations

    8

    h-index

  3. Scientific Reports

    7 publications · 254 citations

    7

    h-index

  4. Experimental Cell Research

    ECR · 7 publications · 263 citations

    7

    h-index

  5. 6

    h-index

1–5