Concepedia

Active Site Design

Active Site Design is a protein engineering strategy within the broader field of enzyme design that involves the rational modification or de novo creation of catalytic residues and binding pockets in a protein scaffold to achieve specific biochemical functions.

93

Publications

6.1K

Citations

441

Authors

181

Institutions

Publications per year

2017–2026

33

Parents

Publications

93

Identification and Regulation of Active Sites on Nanodiamonds: Establishing a Highly Efficient Catalytic System for Oxidation of Organic Contaminants

Penghui Shao, Jiayu Tian, Feng Yang et al. · Advanced Functional Materials · 2018 · 709 citations

, , +17

Site-selective protein-modification chemistry for basic biology and drug development

Nikolaus Krall, Filipa P. da Cruz, Omar Boutureira et al. · Nature Chemistry · 2015 · 582 citations

, , +16

Expanding the Range of Substrate Acceptance of Enzymes: Combinatorial Active‐Site Saturation Test

Manfred T. Reetz, Marco Bocola, José Daniel Carballeira et al. · Angewandte Chemie International Edition · 2005 · 504 citations

, , +14

Electrocatalysis of hydrogen production by active site analogues of the iron hydrogenase enzyme: structure/function relationships

Daesung Chong, Irene P. Georgakaki, Rosario Mejia-Rodriguez et al. · Dalton Transactions · 2003 · 343 citations

, , +17

Composite Active Site of an ABC ATPase

M.S. Junop, Galina Obmolova, Kelly M. Rausch et al. · Molecular Cell · 2001 · 264 citations · Full text

, , +11

1–5 of 93

Authors

441

  1. MB
    Marco Bocola

    RWTH Aachen University, Germany

    4 publications · 684 citations

    4

    h-index

  2. YD
    Yonghong Deng

    Southern University of Science and Technology, China

    3 publications · 205 citations

    3

    h-index

  3. SX
    Song Xue

    Jiangsu University, China

    3 publications · 205 citations

    3

    h-index

  4. SY
    Su Yu

    University of Tennessee at Knoxville, United States

    3 publications · 205 citations

    3

    h-index

  5. GO
    Gustav Oberdorfer

    University of Graz, Austria

    3 publications · 150 citations

    3

    h-index

1–5 of 441

Institutions

181

  1. Weizmann Institute of Science

    Rehovot, Israel

    5 h-index

    17 publications

    1.1K citations

  2. Tsinghua University

    Beijing, China

    4 h-index

    16 publications

    456 citations

  3. Instituto de Catálisis y Petroleoquímica

    Madrid, Spain

    3 h-index

    12 publications

    1.2K citations

  4. Michigan State University

    East Lansing, United States

    3 h-index

    12 publications

    820 citations

  5. Southern Federal University

    Rostov-on-Don, Russia

    2 h-index

    2 publications

    79 citations

  6. Max-Planck-Institut für Kohlenforschung

    Mülheim, Germany

    2 h-index

    10 publications

    3.2K citations

  7. Shenzhen Metro (China)

    Shenzhen, China

    2 h-index

    2 publications

    721 citations

  8. Universität Greifswald

    Greifswald, Germany

    2 h-index

    5 publications

    82 citations

1–8 of 181

Venues

  1. Journal of the American Chemical Society

    JACS · 4 publications · 325 citations

    4

    h-index

  2. Angewandte Chemie International Edition

    3 publications · 614 citations

    3

    h-index

  3. Toxicon

    2 publications · 62 citations

    2

    h-index

  4. Nature

    2 publications · 220 citations

    2

    h-index

  5. Angewandte Chemie

    2 publications · 176 citations

    2

    h-index

1–5