Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity

Nobuya Ishii, Naoki Harada, Eric W. Joseph, +15

Cancer Research

Raf Feedback LimitsRaf ActivityCancer BiologyTumor BiologySignaling Pathway +15

Exploitation of Elevated Extracellular ATP to Specifically Direct Antibody to Tumor Microenvironment

Futa Mimoto, K. Tatsumi, Shun Shimizu, +37

Cell Reports

Cancer ImmunosurveillanceElevated Extracellular AtpMedicineImmunologyBiological Microenvironments +13

Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties

Ikumi Hyohdoh, Noriyuki Furuichi, Toshihiro Aoki, +16

ACS Medicinal Chemistry Letters

EngineeringChemical AnalysisLead IdentificationOrganic ChemistryChemistry +21

Cell binding isoforms of vascular endothelial growth factor-A (VEGF189) contribute to blood flow-distant metastasis of pulmonary adenocarcinoma

Masatake Nishi, Yoshiyuki Abe, Yasushi Tomii, +8

International Journal of Oncology

Increased Vegf189 ExpressionPathologyTumor BiologyAngiogenesisOncology +18

Interleukin 10 expression is correlated with thrombospondin expression and decreased vascular involvement in colon cancer

Tsutomu Kawakami, Tetsuji Tokunaga, Hiroyuki Hatanaka, +12

International Journal of Oncology

T-regulatory CellImmunologyPathologyImmunotherapyInflammation +14

The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors

Toshihiro Aoki, Ikumi Hyohdoh, Noriyuki Furuichi, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryOral BioavailabilitySulfamide Moiety AffordsBiochemistryMedicine +8

The modifier subunit of glutamate cysteine ligase (GCLM) is a molecular target for amelioration of cisplatin resistance in lung cancer

Yoshimasa Inoue, Masashi Tomisawa, Hitoshi Yamazaki, +10

International Journal of Oncology

Cisplatin ResistanceGcl MrnaMedicinePharmacologyGlutamate Cysteine Ligase +11

Human thrombospondin 2 inhibits proliferation of microvascular endothelial cells

Yasushi Tomii, Junichiro Kamochi, Hitoshi Yamazaki, +7

International Journal of Oncology

ImmunologyCancer BiologyTumor BiologyThrombosisAngiogenesis +18

Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning

Toshihiro Aoki, Ikumi Hyohdoh, Noriyuki Furuichi, +16

ACS Medicinal Chemistry Letters

Pharmaceutical ScienceChemoprevention StrategyChemical AnalysisChemical BiologyPharmaceutical Chemistry +22

Unique properties of 189 amino acid isoform of vascular endothelial growth factor in tumorigenesis

Yasushi Tomii, Hitoshi Yamazaki, Nobuko Sawa, +10

International Journal of Oncology

PathologyCell ProliferationTumor BiologyAngiogenesisOncology +19