Ikumi Hyohdoh

Discovery of [5-Amino-1-(2-methyl-3<i>H</i>-benzimidazol-5-yl)pyrazol-4-yl]-(1<i>H</i>-indol-2-yl)methanone (CH5183284/Debio 1347), An Orally Available and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor

Hirosato Ebiike, Naoki Taka, Masayuki Matsushita et al. · Journal of Medicinal Chemistry · 2016 · 37 citations · Full text

Drug Target, Chemoprevention Strategy, Human Growth +25

Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties

Ikumi Hyohdoh, Noriyuki Furuichi, Toshihiro Aoki et al. · ACS Medicinal Chemistry Letters · 2013 · 36 citations · Full text

Engineering, Chemical Analysis, Lead Identification +23

The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors

Toshihiro Aoki, Ikumi Hyohdoh, Noriyuki Furuichi et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 21 citations · Full text

Medicinal Chemistry, Oral Bioavailability, Sulfamide Moiety Affords +10

Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning

Toshihiro Aoki, Ikumi Hyohdoh, Noriyuki Furuichi et al. · ACS Medicinal Chemistry Letters · 2014 · 17 citations · Full text

Pharmaceutical Science, Chemoprevention Strategy, Chemical Analysis +24