2-[11C]Thymidine Positron Emission Tomography as an Indicator of Thymidylate Synthase Inhibition in Patients Treated With AG337

Paula Wells, Eric O. Aboagye, Roger N. Gunn, +8

JNCI Journal of the National Cancer Institute

Thymidylate synthase: A target for anticancer drug design

K.R. Harrap, Ann L. Jackman, David R. Newell, +3

Advances in Enzyme Regulation

MedicineSynthetic BiologyThymidylate SynthaseAnti-cancer AgentDrug Development +2

Thiothymidine combined with UVA as a potential novel therapy for bladder cancer

Simon W. Pridgeon, Rakesh Heer, G. A. Taylor, +6

British Journal of Cancer

Quinazoline antifolates with dual biochemical loci of action. Biochemical and biological studies directed towards overcoming methotrexate resistance

A H Calvert, Terence R. Jones, P J Dady, +4

European Journal of Cancer (1965)

Pharmaceutical ChemistryBiochemistryMedicinePharmacotherapyBiological Studies +7

Clinical pharmacokinetic and pharmacodynamic studies with the nonclassical antifolate thymidylate synthase inhibitor 3, 4-dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)-quinazolone dihydrochloride (AG337) given by 24-hour continuous intravenous infusion.

Imran Rafi, G. A. Taylor, J A Calvete, +7

PubMed

PharmacotherapyClinical PharmacokineticPharmacodynamic StudiesPharmacodynamic ModelingTranslational Pharmacology +14

Enhancement of the therapeutic effectiveness of methotrexate and protection of normal proliferating tissues with purines and pyrimidines

K.R. Harrap, G. A. Taylor, George P. Browman

Chemico-Biological Interactions

MedicineClinical PharmacologyToxicologyPharmacotherapyPharmacology +1

Preclinical and phase I clinical studies with the nonclassical antifolate thymidylate synthase inhibitor nolatrexed dihydrochloride given by prolonged administration in patients with solid tumors.

Imran Rafi, Alan V. Boddy, J A Calvete, +9

Journal of Clinical Oncology

Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo

Jane L. Armstrong, G. A. Taylor, Huw D. Thomas, +3

British Journal of Cancer

Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines.

Michael R. Barnes, EJ Estlin, G. A. Taylor, +7

PubMed

Nm RaltitrexedDrug-induced InhibitionMedicineImmunologyCellular Pharmacology +8

Some Observations on the Reversibility of Methotrexate Toxicity in Normal Proliferating Tissues2

J A Straw, D C Talbot, G. A. Taylor, +1

JNCI Journal of the National Cancer Institute

ImmunologyPathologyNormal Proliferating Tissues2Purine DeficiencyToxicological Mechanism +15