Timothy P. Burkholder

Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, in Human Cancer Cells

Bo Tan, Debra A. Young, Zhao-Hai Lu et al. · Journal of Biological Chemistry · 2012 · 173 citations · Full text

Glycobiology, Nad+ Biosynthesis, Metabolic Remodeling +19

Substituted 3-Imidazo[1,2-<i>a</i>]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino- [6,7,1-<i>hi</i>]indol-7-yl)pyrrole-2,5-diones as Highly Selective and Potent Inhibitors of Glycogen Synthase Kinase-3

Thomas A. Engler, James R. Henry, Sushant Malhotra et al. · Journal of Medicinal Chemistry · 2004 · 100 citations · Full text

Insulin Receptor, Pharmaceutical Chemistry, Insulin Signaling +18

Synthesis via vinyl sulfones. 38. Total synthesis of the cephalotaxus alkaloids dl-cephalotaxine, dl-11-hydroxycephalotaxine, and dl-drupacine

Timothy P. Burkholder, Phillip L. Fuchs · Journal of the American Chemical Society · 1990 · 75 citations

Natural Product Synthesis, Bioorganic Chemistry, Biochemistry +13

Discovery and characterization of LY2784544, a small-molecule tyrosine kinase inhibitor of JAK2V617F

Liandong Ma, Joshua R. Clayton, Richard A. Walgren et al. · Blood Cancer Journal · 2013 · 64 citations · Full text

Synthesis via vinyl sulfones. 27. Total synthesis of cephalotaxine. The first example of an intramolecular [4 + 2] cycloaddition where the dienophile has been delivered from the face opposite to the tethering moiety

Timothy P. Burkholder, P. L. Fuchs · Journal of the American Chemical Society · 1988 · 60 citations

Bioorganic Chemistry, Engineering, Face Opposite +11