Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells

Tuure Kinnunen, Nicolas Chamberlain, Henner Morbach, +10

Blood

Specific peripheral B cell tolerance defects in patients with multiple sclerosis

Tuure Kinnunen, Nicolas Chamberlain, Henner Morbach, +7

Journal of Clinical Investigation

Neurological DisorderImmunologyB Cell TolerancePathologyImmunotherapy +17

CVID-associated TACI mutations affect autoreactive B cell selection and activation

Neil Romberg, Nicolas Chamberlain, David Saadoun, +15

Journal of Clinical Investigation

Adaptive Immune SystemGeneticsHumoral ResponseImmunologyAntibody Deficiency +18

Self-reactive VH4-34–expressing IgG B cells recognize commensal bacteria

Jean‐Nicolas Schickel, Salomé Glauzy, Yen-Shing Ng, +10

The Journal of Experimental Medicine

Rituximab does not reset defective early B cell tolerance checkpoints

Nicolas Chamberlain, Christopher Massad, Tyler Oe, +3

Journal of Clinical Investigation

Adaptive Immune SystemHumoral ResponseImmunologyImmune RegulationImmune System +21

Wiskott–Aldrich Syndrome protein deficiency perturbs the homeostasis of B-cell compartment in humans

Maria Carmina Castiello, Marita Bosticardo, Francesca Pala, +12

Journal of Autoimmunity

Conjugated bile acids attenuate allergen-induced airway inflammation and hyperresposiveness by inhibiting UPR transducers

Emily M. Nakada, Nirav R. Bhakta, Bethany R. Korwin-Mihavics, +14

JCI Insight

Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics

Nicolas Chamberlain, Bethany R. Korwin-Mihavics, Emily M. Nakada, +9

Redox Biology

Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint

Tineke Cantaert, Jean‐Nicolas Schickel, Jason M. Bannock, +24

Journal of Clinical Investigation

Lentiviral-mediated gene therapy restores B cell tolerance in Wiskott-Aldrich syndrome patients

Francesca Pala, Henner Morbach, Maria Carmina Castiello, +11

Journal of Clinical Investigation

Lymphocyte DevelopmentImmunologyB Cell ToleranceImmunologic MechanismImmunotherapy +16