A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production

Hua Yu, Chiara Borsotti, Jean‐Nicolas Schickel, +10

Blood

Self-reactive VH4-34–expressing IgG B cells recognize commensal bacteria

Jean‐Nicolas Schickel, Salomé Glauzy, Yen-Shing Ng, +10

The Journal of Experimental Medicine

Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis

Nina K. Serwas, Birgit Hoeger, Rico Chandra Ardy, +39

Nature Communications

Impaired TLR9 responses in B cells from patients with systemic lupus erythematosus

Vincent Gies, Jean‐Nicolas Schickel, Sophie Jung, +13

JCI Insight

Adaptive Immune SystemImmunologyImmune RegulationPathologyImmunotherapy +15

PTPN22 inhibition resets defective human central B cell tolerance

Jean‐Nicolas Schickel, Marcel Kuhny, Alessia Baldo, +10

Science Immunology

CD19 controls Toll-like receptor 9 responses in human B cells

Henner Morbach, Jean‐Nicolas Schickel, Charlotte Cunningham‐Rundles, +4

Journal of Allergy and Clinical Immunology

InflammationToll-like ReceptorsHuman B CellsInnate Immune SystemImmunology +6

Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint

Tineke Cantaert, Jean‐Nicolas Schickel, Jason M. Bannock, +24

Journal of Clinical Investigation

The V Gene Repertoires of Classical and Atypical Memory B Cells in Malaria-Susceptible West African Children

Severin Zinöcker, Christine E. Schindler, Jeff Skinner, +8

The Journal of Immunology

TNF receptor superfamily member 13b (TNFRSF13B) hemizygosity reveals transmembrane activator and CAML interactor haploinsufficiency at later stages of B-cell development

Neil Romberg, Manmeet Virdee, Nicolas Chamberlain, +10

Journal of Allergy and Clinical Immunology

Member 13BSignal TransductionSignaling PathwayImmune Cell DevelopmentB-cell Development +8

Synovial fibroblasts promote immunoglobulin class switching by a mechanism involving BAFF

Ghada Alsaleh, Antoine François, Anne‐Marie Knapp, +6

European Journal of Immunology

Humoral ResponseImmunologyPathologyImmunologic MechanismAntigen Processing +19