2-Aminothiazole as a Novel Kinase Inhibitor Template. Structure−Activity Relationship Studies toward the Discovery of <i>N</i> -(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (Dasatinib, BMS-354825) as a Potent <i>pan</i> -Src Kinase Inhibitor

Jagabandhu Das, Ping Chen, Derek Norris, +18

Journal of Medicinal Chemistry

A new facile method for the synthesis of 1-arylimidazole-5-carboxylates

Bang‐Chi Chen, Mark S. Bednarz, Joseph E. Sundeen, +4

Tetrahedron Letters

EngineeringOrganic ChemistrySynthesis MethodSynthetic ChemistryBiomolecular Engineering +1

Molecular design, synthesis, and structure–Activity relationships leading to the potent and selective p56lck inhibitor BMS-243117

Jagabandhu Das, James C. Lin, Robert V. Moquin, +11

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineDrug Discovery +12

Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56Lck

John Wityak, Jagabandhu Das, Robert V. Moquin, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetBiochemistryInitial SarNatural Sciences +9

Acridone-Based Inhibitors of Inosine 5‘-Monophosphate Dehydrogenase:  Discovery and SAR Leading to the Identification of <i>N</i>-(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419)

Scott H. Watterson, Ping Chen, Yufen Zhao, +20

Journal of Medicinal Chemistry

Sar LeadingPharmaceutical ScienceInosine 5PharmacotherapyChemical Biology +15

Total Synthesis of <i>d</i>,<i>l</i>-Isospongiadiol:  An Intramolecular Radical Cascade Approach to Furanoditerpenes

P. A. ZORETIC, Ming Wang, Yong‐Zheng Zhang, +2

The Journal of Organic Chemistry

BiosynthesisStereogenic CentersEngineeringBiochemistryNatural Sciences +11

Discovery of <i>N</i>-[2-[2-[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-<i>N</i>-methyl-4- morpholineacetamide as a Novel and Potent Inhibitor of Inosine Monophosphate Dehydrogenase with Excellent in Vivo Activity

T. G. Murali Dhar, Zhongqi Shen, Junqing Guo, +20

Journal of Medicinal Chemistry

Potent InhibitorPharmacotherapyChemical BiologyPharmaceutical ChemistryMedicinal Chemistry +15

Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase

William J. Pitts, Junqing Guo, T. G. Murali Dhar, +12

Bioorganic & Medicinal Chemistry Letters

PharmacologyTriazine InhibitorsBiochemistryNatural Product Synthesis

Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3

Scott H. Watterson, T. G. Murali Dhar, Shelley K. Ballentine, +8

Bioorganic & Medicinal Chemistry Letters

Novel Indole-based InhibitorsMedicinal ChemistryHydrogen Bond AcceptorsBiochemistryNatural Sciences +8

Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56Lck

Ping Chen, Derek Norris, Edwin J. Iwanowicz, +17

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBioorganic ChemistryBiochemistryInitial SarNatural Sciences +8