Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

Wan Huang, Anantha S. Metlakunta, Nikolaos Dedousis, +5

Diabetes

Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c+ Cells in Adipose Tissue and Liver

Maja Stefanović-Račić, Xiao Yang, Michael S. Turner, +9

Diabetes

ImmunologyImmune RegulationFatty Liver DiseaseImmune DysregulationInflammation +19

Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle

Michael Radin, Sandeep Sinha, Bankim A. Bhatt, +2

Diabetologia

Insulin ResistanceMetabolic SyndromeRodent Skeletal MuscleMolecular PhysiologyMedicine +9

Adropin reduces blood glucose levels in mice by limiting hepatic glucose production

Dharendra Thapa, Bingxian Xie, Janet R. Manning, +9

Physiological Reports

Glucose ToleranceInsulin SignalingOxidative StressGastrointestinal Peptide HormoneObesity +17

DNA methylation alters transcriptional rates of differentially expressed genes and contributes to pathophysiology in mice fed a high fat diet

Pili Zhang, Tianjiao Chu, Nikolaos Dedousis, +11

Molecular Metabolism

Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities

Daniel B. Harmon, W. Kyle Mandler, Ian Sipula, +14

Diabetes

Cardiolipin deficiency elevates susceptibility to a lipotoxic hypertrophic cardiomyopathy

Laura Cole, Edgard M. Mejia, Genevieve C. Sparagna, +7

Journal of Molecular and Cellular Cardiology

CardiomyopathyHeart FailureCardiovascular DiseasePhysiologyCardiology +4

Kupffer cells facilitate the acute effects of leptin on hepatic lipid metabolism

Anantha S. Metlakunta, Wan Huang, Maja Stefanović-Račić, +3

American Journal of Physiology-Endocrinology and Metabolism

ImmunologyAcute EffectsInsulin SignalingGastrointestinal Peptide HormoneInflammation +18

Similar degrees of obesity induced by diet or aging cause strikingly different immunologic and metabolic outcomes

Kanthi Bangalore Krishna, Maja Stefanović-Račić, Nikolaos Dedousis, +2

Physiological Reports

Hepatocyte-derived GDF15 suppresses feeding and improves insulin sensitivity in obese mice

Bingxian Xie, Anjana Murali, Amber Vandevender, +11

iScience