Proteomic alterations of distinct mitochondrial subpopulations in the type 1 diabetic heart: contribution of protein import dysfunction

Walter A. Baseler, Erinne R. Dabkowski, Courtney Williamson, +5

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Mitochondrial DysfunctionMitochondrial Protein ImportMitochondrial BiologyInsulin SignalingOxidative Stress +15

miR-141 as a regulator of the mitochondrial phosphate carrier (Slc25a3) in the type 1 diabetic heart

Walter A. Baseler, Dharendra Thapa, Rajaganapathi Jagannathan, +3

American Journal of Physiology-Cell Physiology

Mitochondrial Phosphate CarrierMitochondrial Atp ProductionInsulin SignalingMetabolic SyndromeType 1 +15

Translational Regulation of the Mitochondrial Genome Following Redistribution of Mitochondrial MicroRNA in the Diabetic Heart

Rajaganapathi Jagannathan, Dharendra Thapa, C.E. Nichols, +7

Circulation Cardiovascular Genetics

Adropin regulates pyruvate dehydrogenase in cardiac cells via a novel GPCR-MAPK-PDK4 signaling pathway

Dharendra Thapa, Michael W. Stoner, Manling Zhang, +6

Redox Biology

The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA

Dharendra Thapa, Kaiyuan Wu, Michael W. Stoner, +14

Journal of Biological Chemistry

Protein Acetylase Gcn5l1Mitochondrial FunctionBiochemistryLiver PhysiologyPhysiology +6

Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced fatty acid oxidation in the heart

Dharendra Thapa, Manling Zhang, Janet R. Manning, +5

American Journal of Physiology-Heart and Circulatory Physiology

Functional deficiencies of subsarcolemmal mitochondria in the type 2 diabetic human heart

Tara L. Croston, Dharendra Thapa, Anthony A. Holden, +8

American Journal of Physiology-Heart and Circulatory Physiology

Cardiac MuscleHeart FailureMitochondrial DysfunctionOxidative StressMetabolic Syndrome +16

Reversal of mitochondrial proteomic loss in Type 1 diabetic heart with overexpression of phospholipid hydroperoxide glutathione peroxidase

Walter A. Baseler, Erinne R. Dabkowski, Rajaganapathi Jagannathan, +9

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Glutathione Peroxidase 4Mitochondrial DysfunctionLipid PeroxidationMitochondrial BiologyRedox Biology +14

Adropin treatment restores cardiac glucose oxidation in pre-diabetic obese mice

Dharendra Thapa, Bingxian Xie, Manling Zhang, +9

Journal of Molecular and Cellular Cardiology

ObesityMetabolic SyndromeDiabetes ManagementInsulin ManagementPhysiology +10

Transgenic overexpression of mitofilin attenuates diabetes mellitus-associated cardiac and mitochondria dysfunction

Dharendra Thapa, C.E. Nichols, Sara E. Lewis, +7

Journal of Molecular and Cellular Cardiology

Mitochondria DysfunctionMetabolic SyndromeCardiomyopathyHeart FailureCardiovascular Disease +10