The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells

Marco Barazas, Stefano Annunziato, Stephen J. Pettitt, +17

Cell Reports

Truncated FGFR2 is a clinically actionable oncogene in multiple cancers

Daniel Zingg, Jinhyuk Bhin, Julia Yemelyanenko, +45

Nature

MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling

Dario Zimmerli, Chiara Svetlana Brambillasca, Francien Talens, +26

Nature Communications

<i>In situ</i> CRISPR‐Cas9 base editing for the development of genetically engineered mouse models of breast cancer

Stefano Annunziato, Catrin Lutz, Linda Henneman, +18

The EMBO Journal

EngineeringTransgenic Mouse ModelsGenetic EngineeringMouse ModelsBreast Cancer +7

Homologous recombination deficiency derived from whole-genome sequencing predicts platinum response in triple-negative breast cancers

Petra ter Brugge, Sarah C. Moser, Ivan Bièche, +30

Nature Communications

A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression

Stefan J. Hutten, Roebi de Bruijn, Catrin Lutz, +25

Cancer Cell

Breast OncologyPathologyTumor BiologyOncologyTumor Heterogeneity +15

Luminal breast cancer identity is determined by loss of glucocorticoid receptor activity

Stefan Preković, Theofilos Chalkiadakis, Merel Roest, +21

EMBO Molecular Medicine

Mechanisms that clear mutations drive field cancerization in mammary tissue

Marta Ciwinska, Hendrik A. Messal, Hristina R Hristova, +9

Nature

Breast OncologySomatic VariantMedicineMammary GlandPathology +7

Rat Models of Hormone Receptor-Positive Breast Cancer

Raquel Nicotra, Catrin Lutz, Hendrik A. Messal, +1

Journal of Mammary Gland Biology and Neoplasia

MYC promotes immune-suppression in TNBC via inhibition of IFN signaling

Dario Zimmerli, Chiara Svetlana Brambillasca, Francien Talens, +21

ImmunologyImmune RegulationImmunoeditingImmunologic MechanismInnate Immunity +16