ATF4-Mediated Induction of 4E-BP1 Contributes to Pancreatic β Cell Survival under Endoplasmic Reticulum Stress

Suguru Yamaguchi, Hisamitsu Ishihara, Takahiro Yamada, +12

Cell Metabolism

Atf4-mediated InductionTranscriptional RegulationSystems BiologySignal TransductionSignaling Pathway +11

MicroRNAs 106b and 222 Improve Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes via Pancreatic β-Cell Proliferation

Sohei Tsukita, Tetsuya Yamada, Kei Takahashi, +14

EBioMedicine

ImmunologyInsulin SignalingMetabolic SyndromeInsulin-deficient DiabetesCorresponding Mirna Mimics +18

Dapagliflozin, a Sodium-Glucose Co-Transporter 2 Inhibitor, Acutely Reduces Energy Expenditure in BAT via Neural Signals in Mice

Yumiko Chiba, Tetsuya Yamada, Sohei Tsukita, +11

PLoS ONE

Sglt2i TreatmentDapagliflozin TreatmentMetabolic RemodelingSodium-glucose Co-transporter 2Obesity +20

Activation of the Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones

Yoichiro Asai, Tetsuya Yamada, Sohei Tsukita, +23

Gastroenterology

Olfactory receptors are expressed in pancreatic β-cells and promote glucose-stimulated insulin secretion

Yuichiro Munakata, Tetsuya Yamada, Junta Imai, +15

Scientific Reports

Chronic mild stress alters circadian expressions of molecular clock genes in the liver

Kei Takahashi, Tetsuya Yamada, Sohei Tsukita, +10

American Journal of Physiology-Endocrinology and Metabolism

Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation

Yohei Kawana, Junta Imai, Yosuke M. Morizawa, +23

Nature Biomedical Engineering

Inhibition of Plasminogen Activator Inhibitor-1 Activation Suppresses High Fat Diet-Induced Weight Gain via Alleviation of Hypothalamic Leptin Resistance

Shinichiro Hosaka, Tetsuya Yamada, Kei Takahashi, +14

Frontiers in Pharmacology

Inter-organ insulin-leptin signal crosstalk from the liver enhances survival during food shortages

Kei Takahashi, Tetsuya Yamada, Shinichiro Hosaka, +14

Cell Reports

Roles of <scp>FoxM1</scp>‐driven basal β‐cell proliferation in maintenance of β‐cell mass and glucose tolerance during adulthood

Masato Kohata, Junta Imai, Tomohito Izumi, +15

Journal of Diabetes Investigation