Hisamitsu Ishihara

Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets

Hisamitsu Ishihara, Tomoichiro Asano, Katsunori Tsukuda et al. · Diabetologia · 1993 · 453 citations · Full text

Molecular Physiology, Signal Transduction, Glucose Metabolism +10

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

Sonya G. Fonseca, Shinsuke Ishigaki, Christine M. Oslowski et al. · Journal of Clinical Investigation · 2010 · 394 citations · Full text

Genetics, Er Stress, Insulin Signaling +18

Islet β-cell secretion determines glucagon release from neighbouring α-cells

Hisamitsu Ishihara, Pierre Maechler, Asllan Gjinovci et al. · Nature Cell Biology · 2003 · 381 citations

Molecular Physiology, Signal Transduction, Glucagon Release +10

Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial

Kohjiro Ueki, Takayoshi Sasako, Yukiko Okazaki et al. · The Lancet Diabetes & Endocrinology · 2017 · 300 citations

Non-pharmacological Intervention, Diabetes Management, Cardiovascular Disease +9

A Critical Role for a Rho-Associated Kinase, p160ROCK, in Determining Axon Outgrowth in Mammalian CNS Neurons

Haruhiko Bito, Tomoyuki Furuyashiki, Hisamitsu Ishihara et al. · Neuron · 2000 · 293 citations · Full text

Mammalian Cns Neurons, Molecular Neuroscience, Developmental Biology +12