WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic β-cells

Takahiro Yamada, Hisamitsu Ishihara, Akira Tamura, +10

Human Molecular Genetics

ATF4-Mediated Induction of 4E-BP1 Contributes to Pancreatic β Cell Survival under Endoplasmic Reticulum Stress

Suguru Yamaguchi, Hisamitsu Ishihara, Takahiro Yamada, +12

Cell Metabolism

Atf4-mediated InductionTranscriptional RegulationSystems BiologySignal TransductionSignaling Pathway +11

WFS1 protein modulates the free Ca²⁺ concentration in the endoplasmic reticulum

Daisuke Takei, Hisamitsu Ishihara, Suguru Yamaguchi, +5

FEBS Letters

Molecular BiologyCytoskeletonWfs1 ProteinCellular PhysiologySignaling Pathway +16

Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance

Masahiro Usui, Suguru Yamaguchi, Yasuhiro Tanji, +7

Metabolism

ObesityInsulin ResistanceMetabolic SyndromeAtf6α-null MiceMetabolic Disorder +11

Involvement of Endoplasmic Stress Protein C/EBP Homologous Protein in Arteriosclerosis Acceleration With Augmented Biological Stress Responses

Junhong Gao, Yasushi Ishigaki, Tetsuya Yamada, +11

Circulation

Direct Correlation Between Ischemic Injury and Extracellular Glycine Concentration in Mice With Genetically Altered Activities of the Glycine Cleavage Multienzyme System

Masaya Oda, Shigeo Kure, Taku Sugawara, +10

Stroke

Endoplasmic reticulum stress and N-glycosylation modulate expression of WFS1 protein

Suguru Yamaguchi, Hisamitsu Ishihara, Akira Tamura, +5

Biochemical and Biophysical Research Communications

Reductive StressProtein FunctionSignal TransductionMedicineNatural Sciences +9

The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion

Yusuke Nakatsu, Keiichi Mori, Yasuka Matsunaga, +11

Journal of Biological Chemistry

BiochemistryNatural SciencesDiabetesβ-Cell ProliferationMetabolic Regulation +6

Cell type-specific activation of metabolism reveals that β-cell secretion suppresses glucagon release from α-cells in rat pancreatic islets

Rui Takahashi, Hisamitsu Ishihara, Akira Tamura, +6

American Journal of Physiology-Endocrinology and Metabolism

Efficient and controlled gene expression in mouse pancreatic islets by arterial delivery of tetracycline-inducible adenoviral vectors

Rui Takahashi, Hisamitsu Ishihara, Kazuma Takahashi, +5

Journal of Molecular Endocrinology