Dual base editor catalyzes both cytosine and adenine base conversions in human cells

Xiaohui Zhang, Biyun Zhu, Liang Chen, +23

Nature Biotechnology

Cellular EnzymologyBiochemistryAdenine Base ConversionsHuman CellsNatural Sciences +9

Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain

Xiaohui Zhang, Liang Chen, Biyun Zhu, +17

Nature Cell Biology

BiochemistryNatural SciencesOligonucleotideMolecular BiologyDna Replication +6

Cas9-nickase–mediated genome editing corrects hereditary tyrosinemia in rats

Yanjiao Shao, Liren Wang, Nana Guo, +14

Journal of Biological Chemistry

Amelioration of an Inherited Metabolic Liver Disease through Creation of a De Novo Start Codon by Cytidine Base Editing

Lei Yang, Liren Wang, Yanan Huo, +14

Molecular Therapy

Enhanced genome editing to ameliorate a genetic metabolic liver disease through co-delivery of adeno-associated virus receptor

Shuming Yin, Lie Ma, Tingting Shao, +14

Science China Life Sciences

EngineeringHepatologyLiver PhysiologyAdeno-associated Virus ReceptorGenetic Engineering +11

Engineering of efficiency-enhanced Cas9 and base editors with improved gene therapy efficacies

Shuming Yin, Mei Zhang, Yang Liu, +14

Molecular Therapy

Engineering APOBEC3A deaminase for highly accurate and efficient base editing

Lei Yang, Yanan Huo, Man Wang, +20

Nature Chemical Biology

Molecular BiologyGenome EditingBiomolecular EngineeringApobec3a Deaminase

Long-term correction of hemophilia B through CRISPR/Cas9 induced homology-independent targeted integration

Xi Chen, Xuran Niu, Yang Liu, +14

Journal of genetics and genomics/Journal of Genetics and Genomics

Gene TherapiesOff-target EffectNatural SciencesLong-term CorrectionImmunology +9

Phylogeographic analysis of the fir species in southern China suggests complex origin and genetic admixture

Yanling Peng, Shuming Yin, Jing Wang, +4

Annals of Forest Science

BiologyGenetic DiversityPhylogeneticsMolecular EcologyBiogeography +12

A de novo missense mutation in MPP2 confers an increased risk of Vogt–Koyanagi–Harada disease as shown by trio-based whole-exome sequencing

Xianyang Liu, Jiayu Meng, Xingyun Liao, +12

Cellular and Molecular Immunology

Ocular DiseaseEngineeringGeneticsPathologyMolecular Genetics +18