Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors

Patrick Y. S. Lam, Prabhakar K. Jadhav, Charles J. Eyermann, +12

Science

Combinatorial ChemistryBioorganic ChemistryNonpeptide Cyclic UreasChemistryHuman Immunodeficiency Virus +16

Cyclic HIV Protease Inhibitors:  Synthesis, Conformational Analysis, P2/P2‘ Structure−Activity Relationship, and Molecular Recognition of Cyclic Ureas

Patrick Y. S. Lam, Yu Ru, Prabhakar K. Jadhav, +24

Journal of Medicinal Chemistry

Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450

C. Nicholas Hodge, Paul E. Aldrich, Lee T. Bacheler, +17

Chemistry & Biology

Hiv-1 ProteaseBiochemistryMedicineAntiviral Drug DevelopmentDmp 450 +7

Preparation and Structure−Activity Relationship of Novel P1/P1‘-Substituted Cyclic Urea-Based Human Immunodeficiency Virus Type-1 Protease Inhibitors

David A. Nugiel, Kim Jacobs, Tabitha V. Worley, +10

Journal of Medicinal Chemistry

Bioorganic ChemistryAntiviral DrugChemical BiologyPharmaceutical ChemistryNovel P1/p1 ‘ +17

Potent cyclic urea HIV protease inhibitors with benzofused heterocycles as P2/P2′ groups

James D. Rodgers, Barry L. Johnson, Haisheng Wang, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryP2/p2′ GroupsHeterocyclicBiochemistryMedicine +8

Selection conditions affect the evolution of specific mutations in the reverse transcriptase gene associated with resistance to DMP 266

Dean L. Winslow, Sena Garber, Carol Reid, +4

AIDS

Determinants of the human immunodeficiency virus type 1 p15NC-RNA interaction that affect enhanced cleavage by the viral protease

N Sheng, Steve C. Pettit, R.J. Tritch, +4

Journal of Virology

Viral ReplicationGag PrecursorImmunologyMolecular BiologyViral Protease +19

Nonpeptide Cyclic Cyanoguanidines as HIV-1 Protease Inhibitors:  Synthesis, Structure−Activity Relationships, and X-ray Crystal Structure Studies

Prabhakar K. Jadhav, Francis J. Woerner, Patrick Y. S. Lam, +12

Journal of Medicinal Chemistry

DPC 817: a Cytidine Nucleoside Analog with Activity against Zidovudine- and Lamivudine-Resistant Viral Variants

Raymond F. Schinazi, John W. Mellors, Holly Bazmi, +17

Antimicrobial Agents and Chemotherapy

Design, Synthesis, and Evaluation of Tetrahydropyrimidinones as an Example of a General Approach to Nonpeptide HIV Protease Inhibitors

George V. De Lucca, Jing Liang, Paul E. Aldrich, +5

Journal of Medicinal Chemistry