John-Paul Upton

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

Dan Han, Alana G. Lerner, Lieselotte Vande Walle et al. · Cell · 2009 · 798 citations · Full text

Transcriptional Regulation, Signal Transduction, Divergent Cell Fates +11

IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

John-Paul Upton, Likun Wang, Dan Han et al. · Science · 2012 · 632 citations · Full text

USP7 small-molecule inhibitors interfere with ubiquitin binding

Lorna Kategaya, Paola Di Lello, Lionel Rougé et al. · Nature · 2017 · 332 citations · Full text

Molecular Docking, Ubiquitin Binding, Drug Target +7

Caspase-2 Cleavage of BID Is a Critical Apoptotic Signal Downstream of Endoplasmic Reticulum Stress

John-Paul Upton, Kathryn Austgen, Mari Nishino et al. · Molecular and Cellular Biology · 2008 · 188 citations · Full text

Mitophagy, Apoptosis, Immunology +20

A kinase inhibitor activates the IRE1α RNase to confer cytoprotection against ER stress

Dan Han, John-Paul Upton, Andrew Hagen et al. · Biochemical and Biophysical Research Communications · 2007 · 51 citations

Signal Transduction, Kinase Inhibitor, Signaling Pathway +12