Concepedia

A kinase inhibitor activates the IRE1α RNase to confer cytoprotection against ER stress

Dan Han, John-Paul Upton, Andrew Hagen, Joseph A. Callahan, Scott A. Oakes, Feroz R. Papa

Biochemical and Biophysical Research Communications · 2007 · 51 citations · 18 references

DOI

Concepts

References

18

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

Hiderou Yoshida, Toshie Matsui, Akira Yamamoto et al. · Cell · 2001 · 4.1K citations · Full text

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Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

Fumihiko Urano, Xiao-Zhong Wang, Anne Bertolotti et al. · Science · 2000 · 3K citations

, , +16

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

Marcella A. Calfon, Huiqing Zeng, Fumihiko Urano et al. · Nature · 2002 · 2.9K citations

, , +5

IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response

Jonathan H. Lin, Han Li, Douglas Yasumura et al. · Science · 2007 · 1.4K citations

, , +17

Decay of Endoplasmic Reticulum-Localized mRNAs During the Unfolded Protein Response

Julie Hollien, Jonathan S. Weissman · Science · 2006 · 1.3K citations

, , +17