Gregory Hook

Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein

Vivian Hook, Mark S. Kindy, Gregory Hook · Journal of Biological Chemistry · 2008 · 203 citations · Full text

Protein Secretion, Molecular Biology, Amyloid Precursor Protein +18

Inhibition of cathepsin B reduces β-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate β-secretase of Alzheimer's disease

Vivian Hook, Thomas Toneff, Matthew Bogyo et al. · Biological Chemistry · 2005 · 168 citations

The Cysteine Protease Inhibitor, E64d, Reduces Brain Amyloid-β and Improves Memory Deficits in Alzheimer's Disease Animal Models by Inhibiting Cathepsin B, but not BACE1, β-Secretase Activity

Gregory Hook, Vivian Hook, Mark S. Kindy · Journal of Alzheimer s Disease · 2011 · 110 citations · Full text

Neurodegenerative Diseases, Alzheimer's Disease, Biochemistry +15

Genetic cathepsin B deficiency reduces β-amyloid in transgenic mice expressing human wild-type amyloid precursor protein

Vivian Hook, Mark S. Kindy, Thomas Reinheckel et al. · Biochemical and Biophysical Research Communications · 2009 · 107 citations · Full text

Neurodegenerative Diseases, Disease Mechanism, Genetics +6

Brain Pyroglutamate Amyloid-β is Produced by Cathepsin B and is Reduced by the Cysteine Protease Inhibitor E64d, Representing a Potential Alzheimer's Disease Therapeutic

Gregory Hook, Jin Yu, Thomas Toneff et al. · Journal of Alzheimer s Disease · 2014 · 83 citations · Full text

Molecular Biology, Peptide Science, Brain Pyroglutamate Amyloid-β +23