Thomas Toneff

Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter

Sukkid Yasothornsrikul, Doron C. Greenbaum, Katalin F. Medzihradszky et al. · Proceedings of the National Academy of Sciences · 2003 · 210 citations · Full text

Protein Secretion, Proteasome, Molecular Biology +21

Inhibition of cathepsin B reduces β-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate β-secretase of Alzheimer's disease

Vivian Hook, Thomas Toneff, Matthew Bogyo et al. · Biological Chemistry · 2005 · 168 citations

Tissue-Specific Proteolysis of Huntingtin (htt) in Human Brain: Evidence of Enhanced Levels of N- and C-Terminal htt Fragments in Huntington's Disease Striatum

Liane Mende‐Mueller, Thomas Toneff, Shin‐Rong Hwang et al. · Journal of Neuroscience · 2001 · 158 citations · Full text

Proteasome, Molecular Biology, Disease Striatum +18

Human iPSC Neurons Display Activity-Dependent Neurotransmitter Secretion: Aberrant Catecholamine Levels in Schizophrenia Neurons

Vivian Hook, Kristen Brennand, Yong Sung Kim et al. · Stem Cell Reports · 2014 · 108 citations · Full text

Brain Pyroglutamate Amyloid-β is Produced by Cathepsin B and is Reduced by the Cysteine Protease Inhibitor E64d, Representing a Potential Alzheimer's Disease Therapeutic

Gregory Hook, Jin Yu, Thomas Toneff et al. · Journal of Alzheimer s Disease · 2014 · 83 citations · Full text

Molecular Biology, Peptide Science, Brain Pyroglutamate Amyloid-β +23