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Juliana Camacho-Pereira, Mariana G. Tarragó, Claudia C.S. Chini, +8

Cell Metabolism

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NKG2D-DAP10 triggers human NK cell–mediated killing via a Syk-independent regulatory pathway

Daniel D. Billadeau, Jadee L. Upshaw, Renee A. Schoon, +2

Nature Immunology

Natural Killer CellsSyk-independent Regulatory PathwayApoptosisImmune RegulationImmunology +7

NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells

Jadee L. Upshaw, Laura N. Arneson, Renee A. Schoon, +3

Nature Immunology

Natural Killer CellsSignal TransductionImmunologyNkg2d-mediated SignalingCell Death +6

The Vav–Rac1 Pathway in Cytotoxic Lymphocytes Regulates the Generation of Cell-mediated Killing

Daniel D. Billadeau, Kathryn M. Brumbaugh, Christopher J. Dick, +3

The Journal of Experimental Medicine

Functional Role for Syk Tyrosine Kinase in Natural Killer Cell–mediated Natural Cytotoxicity

Kathryn M. Brumbaugh, Bryce A. Binstadt, Daniel D. Billadeau, +4

The Journal of Experimental Medicine

Fc receptor stimulation of phosphatidylinositol 3-kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity.

Joy D. Bonnema, Larry M. Karnitz, Renee A. Schoon, +2

The Journal of Experimental Medicine

ApoptosisImmunologyNk CellsCell DeathPathology +17

Fc gamma receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells.

Adrian T. Ting, Larry M. Karnitz, Renee A. Schoon, +2

The Journal of Experimental Medicine

ImmunologyNk CellsCell DeathImmunologic MechanismInnate Immunity +17

Dedicator of Cytokinesis 8 Interacts with Talin and Wiskott-Aldrich Syndrome Protein To Regulate NK Cell Cytotoxicity

Hyoungjun Ham, Sabrice Guerrier, Jung-Jin Kim, +5

The Journal of Immunology

Wiskott-aldrich Syndrome ProteinImmune RegulationImmunologyCell DeathNk Cells +17

Interaction between lck and syk Family Tyrosine Kinases in Fcγ Receptor-initiated Activation of Natural Killer Cells

Adrian T. Ting, Christopher J. Dick, Renee A. Schoon, +3

Journal of Biological Chemistry

WASH Knockout T Cells Demonstrate Defective Receptor Trafficking, Proliferation, and Effector Function

Joshua Piotrowski, Timothy S. Gomez, Renee A. Schoon, +2

Molecular and Cellular Biology

T-regulatory CellImmunologyImmune RegulationImmunologic MechanismCd4 T Cell Responses +15