2-Thioxanthines Are Mechanism-based Inactivators of Myeloperoxidase That Block Oxidative Stress during Inflammation

A.K. Tiden, Tove Sjögren, Mats Svensson, +14

Journal of Biological Chemistry

InflammationAnti-inflammatoryBiochemistryRedox RegulatorMedicine +10

Efficient IgG-mediated suppression of primary antibody responses in Fcγ receptor-deficient mice

Mikael C. I. Karlsson, Sara Wernersson, Teresita Díaz de Ståhl, +2

Proceedings of the National Academy of Sciences

Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

Fredrik Jeppsson, Susanna Eketjäll, Juliette Janson, +11

Journal of Biological Chemistry

<i>In vivo</i> enhancement of the specific antibody response via the low‐affinity receptor for IgE

Birgitta Heyman, Tianmin Liu, Susanne Gustavsson

European Journal of Immunology

Sulfonimidamides as Sulfonamides Bioisosteres: Rational Evaluation through Synthetic, in Vitro, and in Vivo Studies with γ‐Secretase Inhibitors

Fernando W. Sehgelmeble, Juliette Janson, Colin Ray, +8

ChemMedChem

Pharmaceutical ScienceSecondary MetaboliteChemical BiologyPharmaceutical ChemistryIncreased Solubility +15

Aminoimidazoles as BACE-1 inhibitors: The challenge to achieve in vivo brain efficacy

Britt‐Marie Swahn, Jörg Holenz, Jacob Kihlström, +14

Bioorganic & Medicinal Chemistry Letters

MedicinePharmacologyBace-1 InhibitorsPharmacological AgentNeuropharmacology +8

Restoration of the Antibody Response to IgE/Antigen Complexes in CD23-Deficient Mice by CD23+ Spleen or Bone Marrow Cells

Susanne Gustavsson, Sara Wernersson, Birgitta Heyman

The Journal of Immunology

Murine Cd23More Ag-specific AbsImmunologyImmune RegulationImmunologic Mechanism +16

Revisiting the peripheral sink hypothesis: inhibiting <scp>BACE</scp>1 activity in the periphery does not alter β‐amyloid levels in the <scp>CNS</scp>

Biljana Georgievska, Susanne Gustavsson, Johan Lundkvist, +10

Journal of Neurochemistry

Neurochemical BiomarkersSynaptic SignalingSocial SciencesNeuroinflammationAlzheimer's Disease +21

Alzheimer's Disease: Presenilin 2-Sparing γ-Secretase Inhibition Is a Tolerable Aβ Peptide-Lowering Strategy

Tomas Borgegård, Susanne Gustavsson, Charlotte B. Nilsson, +21

Journal of Neuroscience

Importance of CD23 for Collagen-Induced Arthritis: Delayed Onset and Reduced Severity in CD23-Deficient Mice

Sandra Kleinau, Pernilla Martinsson, Susanne Gustavsson, +1

The Journal of Immunology

ImmunologyPathologyImmunotherapyPsoriatic ArthritisInflammatory Arthritis +19