A peptide–doxorubicin 'prodrug' activated by prostate-specific antigen selectively kills prostate tumor cells positive for prostate-specific antigen in vivo

Deborah Defeo-Jones, Victor M. Garsky, Bradley K. Wong, +17

Nature Medicine

UrologyProstate Tumor CellsMedicinePeptide EngineeringPeptide Therapeutic +6

Species Variability in Platelet and other Cellular Responsiveness to Thrombin Receptor-derived Peptides

Thomas Connolly, Cindra Condra, Dong-Mei Feng, +5

Thrombosis and Haemostasis

ImmunologyMolecular BiologySpecies VariabilityHamster Thrombin ReceptorThrombosis +18

An Antibody Against the Exosite of the Cloned Thrombin Receptor Inhibits Experimental Arterial Thrombosis in the African Green Monkey

Jacquelynn J. Cook, Gary R. Sitko, Bohumil Bednář, +7

Circulation

The Synthesis of a Prodrug of Doxorubicin Designed to Provide Reduced Systemic Toxicity and Greater Target Efficacy

Victor M. Garsky, Patricia K. Lumma, Dong-Mei Feng, +7

Journal of Medicinal Chemistry

Pharmaceutical SciencePharmacotherapyPharmaceutical ChemistryTumor BiologyDrug Resistance +18

Design, synthesis and bioassays of antagonists of LHRH which have high antiovulatory activity and release negligible histamine

Anders Ljungqvist, Dong-Mei Feng, Pui‐Fun Louisa Tang, +6

Biochemical and Biophysical Research Communications

Release Negligible HistaminePharmaceutical SciencePharmacological StudyBiochemistryMedicine +4

Development of a Potent Thrombin Receptor Ligand

Dong-Mei Feng, Daniel F. Veber, Thomas Connolly, +3

Journal of Medicinal Chemistry

Altmetric Attention ScoreTranslational PharmacologySystems PharmacologyThrombosisMolecular Pharmacology +17

Discovery of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors Incorporating Aminopyridyl Moieties at the P1 Position

Dong-Mei Feng, Stephen J. Gardell, Sidney D. Lewis, +17

Journal of Medicinal Chemistry

Design and Synthesis of a Pro-Drug of Vinblastine Targeted at Treatment of Prostate Cancer with Enhanced Efficacy and Reduced Systemic Toxicity

Stephen F. Brady, Joseph Pawluczyk, Patricia K. Lumma, +10

Journal of Medicinal Chemistry

Medicinal ChemistryUrologyOncologyDrug TargetingPolymer-drug Conjugate +13

PSA-specific and non-PSA-specific conversion of a PSA-targeted peptide conjugate of doxorubicin to its active metabolites.

Bradley K. Wong, Deborah Defeo-Jones, Raymond E. Jones, +6

PubMed

Active MetabolitesPeptide SciencePeptide TherapeuticsPharmacotherapyPsa-targeted Peptide Conjugate +22

A prostate-specific antigen (PSA)-activated vinblastine prodrug selectively kills PSA-secreting cells in vivo.

Deborah Defeo-Jones, Stephen F. Brady, Dong-Mei Feng, +17

PubMed

Molecular PharmacologyUrologyOncologyEndocrine-related CancerGenitourinary Cancer +12