FGF-21 as a novel metabolic regulator

Alexei Kharitonenkov, Tatiyana L. Shiyanova, Anja Köester, +15

Journal of Clinical Investigation

ObesityMetabolic SyndromeNovel Metabolic RegulatorMetabolic DisorderMedicine +12

Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance

William L. Holland, Joseph T. Brozinick, Liping Wang, +12

Cell Metabolism

ObesityMetabolic SyndromeBiochemistryMedicineInsulin Management +9

Disruption of Cortical Actin in Skeletal Muscle Demonstrates an Essential Role of the Cytoskeleton in Glucose Transporter 4 Translocation in Insulin-sensitive Tissues

Joseph T. Brozinick, Eric D. Hawkins, Andrew B. Strawbridge, +1

Journal of Biological Chemistry

Substituted 3-Imidazo[1,2-<i>a</i>]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino- [6,7,1-<i>hi</i>]indol-7-yl)pyrrole-2,5-diones as Highly Selective and Potent Inhibitors of Glycogen Synthase Kinase-3

Thomas A. Engler, James R. Henry, Sushant Malhotra, +26

Journal of Medicinal Chemistry

Insulin ReceptorPharmaceutical ChemistryInsulin SignalingType Ii DiabetesMolecular Pharmacology +16

A Predominant Role of Acyl-CoA:monoacylglycerol Acyltransferase-2 in Dietary Fat Absorption Implicated by Tissue Distribution, Subcellular Localization, and Up-regulation by High Fat Diet

Jingsong Cao, Eric D. Hawkins, Joseph T. Brozinick, +4

Journal of Biological Chemistry

A Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist with a Unique in Vitro Profile and Potent Glucose and Lipid Effects in Rodent Models of Type 2 Diabetes and Dyslipidemia

Anne Reifel‐Miller, Keith A. Otto, Eric D. Hawkins, +18

Molecular Endocrinology

Insulin SignalingMetabolic SyndromeMetabolic SignalingDual AgonistHealth Sciences +15

The development of potent and selective bisarylmaleimide GSK3 inhibitors

Thomas A. Engler, Sushant Malhotra, Timothy P. Burkholder, +24

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacotherapyAnti-cancer AgentDrug Development +3

Absence of Glucagon and Insulin Action Reveals a Role for the GLP-1 Receptor in Endogenous Glucose Production

Lucy S. Jun, Rohn Millican, Eric D. Hawkins, +5

Diabetes

Glucose ToleranceInsulin SignalingMetabolic SyndromeType 1Metabolic Signaling +19

Imidazopyridine and Pyrazolopiperidine Derivatives as Novel Inhibitors of Serine Palmitoyl Transferase

Michaël Génin, Isabel C. Gonzalez Valcarcel, William G. Holloway, +11

Journal of Medicinal Chemistry

Bioorganic ChemistryPharmacotherapyChemical BiologyInsulin SignalingPharmaceutical Chemistry +21

Cardiovascular and Antilipolytic Effects of the Adenosine Agonist GR79236

Linda Merkel, Eric D. Hawkins, Dennis Colussi, +4

Pharmacology