Is platelet activating factor (PAF) a mediator of endotoxin shock?

Zen‐ichi Terashita, Yoshimi Imura, Kohei Nishikawa, +1

European Journal of Pharmacology

InflammationThrombosisThrombopoiesisBlood PlateletHematology +7

In Vitro Antagonistic Properties of a New Angiotensin Type 1 Receptor Blocker, Azilsartan, in Receptor Binding and Function Studies

Mami Ojima, Hideki Igata, Masayuki Tanaka, +8

Journal of Pharmacology and Experimental Therapeutics

Identification of Benzoxazin-3-one Derivatives as Novel, Potent, and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists

Tomoaki Hasui, Nobuyuki Matsunaga, Taiichi Ora, +16

Journal of Medicinal Chemistry

Combinatorial ChemistryCrystal StructureMedicinal ChemistryBenzoxazin-3-one DerivativesScaffold Hopping +11

Inhibition by CV-3988 of the binding of [3H]-platelet activating factor (PAF) to the platelet

Zen‐ichi Terashita, Yoshimi Imura, Kohei Nishikawa

Biochemical Pharmacology

InflammationThrombosisThrombopoiesisSignal TransductionBlood Platelet +11

Comparing myotoxic effects of squalene synthase inhibitor, T-91485, and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors in human myocytes

Tomoyuki Nishimoto, Ryuichi Tozawa, Yuichiro Amano, +3

Biochemical Pharmacology

Human MyocytesBiochemistryMedicineToxicologyPharmacotherapy +8

Lipid‐lowering properties of TAK‐475, a squalene synthase inhibitor, <i>in vivo</i> and <i>in vitro</i>

Tomoyuki Nishimoto, Yuichiro Amano, Ryuichi Tozawa, +4

British Journal of Pharmacology

Comparison of the effects of pioglitazone and rosiglitazone on macrophage foam cell formation

Masao Hirakata, Ryuichi Tozawa, Yoshimi Imura, +1

Biochemical and Biophysical Research Communications

InflammationMedicineAutophagyImmunologyPharmacology +3

Possible role of platelet activating factor (PAF) in disseminated intravascular coagulation (DIC), evidenced by use of a PAF antagonist, CV-3988

Yoshimi Imura, Zen‐ichi Terashita, Kohei Nishikawa

Life Sciences

ThrombopoiesisThrombosisCardiovascular DiseaseBlood PlateletMedicine +10

Effect of candesartan cilexetil (TCV-116) in rats with chronic renal failure

Masakuni Noda, Takanori Matsuo, Ryo Fukuda, +6

Kidney International

UrologyRenal FunctionChronic Renal FailureCandesartan CilexetilMedicine +8

Lipid-lowering effects of TAK-475, a squalene synthase inhibitor, in animal models of familial hypercholesterolemia

Yuichiro Amano, Tomoyuki Nishimoto, Ryu-ichi Tozawa, +3

European Journal of Pharmacology

Metabolic SyndromeLipid-lowering EffectsOxysterolBiochemistryMedicine +9